TY - JOUR
T1 - Programmed cell death acts at different stages of Drosophila neurodevelopment to shape the central nervous system
AU - Pinto-Teixeira, Filipe
AU - Konstantinides, Nikolaos
AU - Desplan, Claude
PY - 2016/8/1
Y1 - 2016/8/1
N2 - Nervous system development is a process that integrates cell proliferation, differentiation, and programmed cell death (PCD). PCD is an evolutionary conserved mechanism and a fundamental developmental process by which the final cell number in a nervous system is established. In vertebrates and invertebrates, PCD can be determined intrinsically by cell lineage and age, as well as extrinsically by nutritional, metabolic, and hormonal states. Drosophila has been an instrumental model for understanding how this mechanism is regulated. We review the role of PCD in Drosophila central nervous system development from neural progenitors to neurons, its molecular mechanism and function, how it is regulated and implemented, and how it ultimately shapes the fly central nervous system from the embryo to the adult. Finally, we discuss ideas that emerged while integrating this information.
AB - Nervous system development is a process that integrates cell proliferation, differentiation, and programmed cell death (PCD). PCD is an evolutionary conserved mechanism and a fundamental developmental process by which the final cell number in a nervous system is established. In vertebrates and invertebrates, PCD can be determined intrinsically by cell lineage and age, as well as extrinsically by nutritional, metabolic, and hormonal states. Drosophila has been an instrumental model for understanding how this mechanism is regulated. We review the role of PCD in Drosophila central nervous system development from neural progenitors to neurons, its molecular mechanism and function, how it is regulated and implemented, and how it ultimately shapes the fly central nervous system from the embryo to the adult. Finally, we discuss ideas that emerged while integrating this information.
KW - Drosophila
KW - apoptosis
KW - neurodevelopment
UR - http://www.scopus.com/inward/record.url?scp=84981734364&partnerID=8YFLogxK
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U2 - 10.1002/1873-3468.12298
DO - 10.1002/1873-3468.12298
M3 - Review article
C2 - 27404003
AN - SCOPUS:84981734364
SP - 2435
EP - 2453
JO - FEBS Letters
JF - FEBS Letters
SN - 0014-5793
ER -