Programmed Supramolecular Assemblies Using Orthogonal Pairs of Heterodimeric Coiled Coil Peptides

Linhai Jiang, Xiaobing Zuo, Jianping Li, Nathaniel J. Traaseth, Kent Kirshenbaum

Research output: Contribution to journalArticlepeer-review


Despite recent progress, it remains challenging to program biomacromolecules to assemble into discrete nanostructures with pre-determined sizes and topologies. We report here a novel strategy to address this challenge. By using two orthogonal pairs of heterodimeric coiled coils as the building blocks, we constructed six discrete supramolecular assemblies, each composed of a prescribed number of coiled coil components. Within these assemblies, different coiled coils were connected via end-to-side covalent linkages strategically pre-installed between the non-complementary pairs. The overall topological features of two highly complex assemblies, a “barbell” and a “quadrilateral” form, were characterized experimentally and were in good agreement to the designs. This work expands the design paradigms for peptide-based discrete supramolecular assemblies and will provide a route for de novo fabrication of functional protein materials.

Original languageEnglish (US)
Article numbere202201895
JournalAngewandte Chemie - International Edition
Issue number27
StatePublished - Jul 4 2022


  • Coiled Coils
  • Heterodimers
  • Nanostructures
  • Peptides
  • Supramolecular Assemblies
  • α-Helices

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry


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