Propagating activity patterns in large-scale inhibitory neuronal networks

J. Rinzel, D. Terman, X. J. Wang, B. Ermentrout

Research output: Contribution to journalArticle

Abstract

The propagation of activity is studied in a spatially structured network model of γ-aminobutyric acid-containing (GABAergic) neurons exhibiting postinhibitory rebound. In contrast to excitatory-coupled networks, recruitment spreads very slowly because cells fire only after the postsynaptic conductance decays, and with two possible propagation models. If the connection strength decreases monotonically with distance (on-center), then propagation occurs in a discontinuous manner. If the self- and nearby connections are absent reversal potential can result in depolarization- mediated eaves that are 25 times faster. Functional and developmental roles for these behaviors and implications for thalamic circuitry are suggested.

Original languageEnglish (US)
Pages (from-to)1351-1355
Number of pages5
JournalScience
Volume279
Issue number5355
DOIs
StatePublished - Feb 27 1998

ASJC Scopus subject areas

  • General

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