Proposed mechanisms for cancer- and treatment-related cognitive changes

John D. Merriman, Diane Von Ah, Christine Miaskowski, Bradley E. Aouizerat

Research output: Contribution to journalArticlepeer-review


Objectives: To review the proposed mechanisms of cognitive changes associated with non-central nervous system cancers and cancer treatment. Data Sources: Review and synthesis of databased publications and review articles. Conclusion: Proposed mechanisms include cytokine upregulation, hormonal changes, neurotransmitter dysregulation, attentional fatigue, genetic predisposition, and comorbid symptoms. Implications for Nursing Practice: Oncology nurses need to understand the multiple mechanisms that may contribute to the development of cancer- and treatment-related cognitive changes so that they can identify patients at high risk and help patients understand why these changes occur.

Original languageEnglish (US)
Pages (from-to)260-269
Number of pages10
JournalSeminars in Oncology Nursing
Issue number4
StatePublished - Nov 2013


  • Cancer
  • Cognition
  • Cytokines
  • Inflammation
  • Neurotransmitters

ASJC Scopus subject areas

  • Oncology(nursing)


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