Prospects for gene-based immunopharmacology in salivary glands

Seiichi Yamano, Bruce J. Baum

Research output: Contribution to journalReview article

Abstract

The clinical potential of gene transfer is increasing. One likely major application of this emerging biotechnology will be for gene therapeutics, the use of a gene as a drug. Salivary glands provide an unusual but increasingly valuable target site for gene transfer. Studies in animal salivary glands from several laboratories, including our own, have provided proof of this concept. In this review, we provide a background and perspective on possible strategies for gene-based immunopharmacology in salivary glands. We use as a target disease model the autoimmune exocrinopathy Sjogren's syndrome.

Original languageEnglish (US)
Pages (from-to)281-286
Number of pages6
JournalJapanese Journal of Pharmacology
Volume82
Issue number4
DOIs
StatePublished - 2000

Keywords

  • Adeno-associated virus
  • Autoimmune disease
  • Cytokine
  • Gene therapeutics
  • Salivary gland

ASJC Scopus subject areas

  • Pharmacology

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