Prospects for gene therapy in human prostate cancer

Michael A. Ficazzola, Samir S. Taneja

Research output: Contribution to journalReview articlepeer-review


Prostate cancer is the most common neoplasm in men and a significant cause of mortality in affected patients. Despite significant advances, current methods of treatment are effective only in the absence of metastatic disease. Gene therapy offers a renewed hope of using the differential characteristics of normal and malignant tissue in constructing treatment strategies. Several clinical trials in prostate cancer gene therapy are currently under way, using immunomodulatory genes, anti-oncogenes, tumor suppressor genes and suicide genes. A continued understanding of the etiological mechanisms involved in the establishment and progression of prostate cancer, along with advances in gene therapy technology, should make gene therapy for prostate cancer therapeutically valuable in the future.

Original languageEnglish (US)
Pages (from-to)494-504
Number of pages11
JournalMolecular Medicine Today
Issue number11
StatePublished - Nov 1 1998

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics


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