Protease-activated receptor 2 (PAR2) protein and transient receptor potential vanilloid 4 (TRPV4) protein coupling is required for sustained inflammatory signaling

Daniel P. Poole; Silvia Amadesi; Nicholas A. Veldhuis; Fe C. Abogadie; Tina Marie Lieu; William Darby; Wolfgang Liedtke; Michael J. Lew; Peter McIntyre; Nigel W. Bunnett

doi:10.1074/jbc.M112.438184

Protease-activated receptor 2 (PAR2) protein and transient receptor potential vanilloid 4 (TRPV4) protein coupling is required for sustained inflammatory signaling

Daniel P. Poole, Silvia Amadesi, Nicholas A. Veldhuis, Fe C. Abogadie, Tina Marie Lieu, William Darby, Wolfgang Liedtke, Michael J. Lew, Peter McIntyre, Nigel W. Bunnett

Molecular Pathobiology

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Receptors activate channels of sensory nerves to cause inflammation and pain by unknown mechanisms. Results: Protease-activated receptor 2 (PAR2) stimulated transient receptor potential vanilloid 4 (TRPV4) by generation of channel agonists. This required a key TRPV4 tyrosine and induced inflammation. Conclusion: PAR2 opens TRPV4 by functional coupling. Significance: Antagonism of PAR2-TRPV4 coupling could alleviate inflammation and pain.

Original language	English (US)
Pages (from-to)	5790-5802
Number of pages	13
Journal	Journal of Biological Chemistry
Volume	288
Issue number	8
DOIs	https://doi.org/10.1074/jbc.M112.438184
State	Published - Feb 22 2013

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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10.1074/jbc.M112.438184

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Poole, D. P., Amadesi, S., Veldhuis, N. A., Abogadie, F. C., Lieu, T. M., Darby, W., Liedtke, W., Lew, M. J., McIntyre, P., & Bunnett, N. W. (2013). Protease-activated receptor 2 (PAR2) protein and transient receptor potential vanilloid 4 (TRPV4) protein coupling is required for sustained inflammatory signaling. Journal of Biological Chemistry, 288(8), 5790-5802. https://doi.org/10.1074/jbc.M112.438184

Protease-activated receptor 2 (PAR2) protein and transient receptor potential vanilloid 4 (TRPV4) protein coupling is required for sustained inflammatory signaling. / Poole, Daniel P.; Amadesi, Silvia; Veldhuis, Nicholas A. et al.
In: Journal of Biological Chemistry, Vol. 288, No. 8, 22.02.2013, p. 5790-5802.

Research output: Contribution to journal › Article › peer-review

Poole, DP, Amadesi, S, Veldhuis, NA, Abogadie, FC, Lieu, TM, Darby, W, Liedtke, W, Lew, MJ, McIntyre, P & Bunnett, NW 2013, 'Protease-activated receptor 2 (PAR2) protein and transient receptor potential vanilloid 4 (TRPV4) protein coupling is required for sustained inflammatory signaling', Journal of Biological Chemistry, vol. 288, no. 8, pp. 5790-5802. https://doi.org/10.1074/jbc.M112.438184

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title = "Protease-activated receptor 2 (PAR2) protein and transient receptor potential vanilloid 4 (TRPV4) protein coupling is required for sustained inflammatory signaling",

abstract = "Background: Receptors activate channels of sensory nerves to cause inflammation and pain by unknown mechanisms. Results: Protease-activated receptor 2 (PAR2) stimulated transient receptor potential vanilloid 4 (TRPV4) by generation of channel agonists. This required a key TRPV4 tyrosine and induced inflammation. Conclusion: PAR2 opens TRPV4 by functional coupling. Significance: Antagonism of PAR2-TRPV4 coupling could alleviate inflammation and pain.",

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AU - Amadesi, Silvia

AU - Veldhuis, Nicholas A.

AU - Abogadie, Fe C.

AU - Lieu, Tina Marie

AU - Darby, William

AU - Liedtke, Wolfgang

AU - Lew, Michael J.

AU - McIntyre, Peter

AU - Bunnett, Nigel W.

PY - 2013/2/22

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AB - Background: Receptors activate channels of sensory nerves to cause inflammation and pain by unknown mechanisms. Results: Protease-activated receptor 2 (PAR2) stimulated transient receptor potential vanilloid 4 (TRPV4) by generation of channel agonists. This required a key TRPV4 tyrosine and induced inflammation. Conclusion: PAR2 opens TRPV4 by functional coupling. Significance: Antagonism of PAR2-TRPV4 coupling could alleviate inflammation and pain.

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Protease-activated receptor 2 (PAR2) protein and transient receptor potential vanilloid 4 (TRPV4) protein coupling is required for sustained inflammatory signaling

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