Protease-activated receptor 2 (PAR2) protein and transient receptor potential vanilloid 4 (TRPV4) protein coupling is required for sustained inflammatory signaling

Daniel P. Poole, Silvia Amadesi, Nicholas A. Veldhuis, Fe C. Abogadie, Tina Marie Lieu, William Darby, Wolfgang Liedtke, Michael J. Lew, Peter McIntyre, Nigel W. Bunnett

Research output: Contribution to journalArticle

Abstract

Background: Receptors activate channels of sensory nerves to cause inflammation and pain by unknown mechanisms. Results: Protease-activated receptor 2 (PAR2) stimulated transient receptor potential vanilloid 4 (TRPV4) by generation of channel agonists. This required a key TRPV4 tyrosine and induced inflammation. Conclusion: PAR2 opens TRPV4 by functional coupling. Significance: Antagonism of PAR2-TRPV4 coupling could alleviate inflammation and pain.

Original languageEnglish (US)
Pages (from-to)5790-5802
Number of pages13
JournalJournal of Biological Chemistry
Volume288
Issue number8
DOIs
StatePublished - Feb 22 2013

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'Protease-activated receptor 2 (PAR2) protein and transient receptor potential vanilloid 4 (TRPV4) protein coupling is required for sustained inflammatory signaling'. Together they form a unique fingerprint.

  • Cite this

    Poole, D. P., Amadesi, S., Veldhuis, N. A., Abogadie, F. C., Lieu, T. M., Darby, W., Liedtke, W., Lew, M. J., McIntyre, P., & Bunnett, N. W. (2013). Protease-activated receptor 2 (PAR2) protein and transient receptor potential vanilloid 4 (TRPV4) protein coupling is required for sustained inflammatory signaling. Journal of Biological Chemistry, 288(8), 5790-5802. https://doi.org/10.1074/jbc.M112.438184