TY - JOUR
T1 - Protease-activated receptors
T2 - novel PARtners in innate immunity
AU - Shpacovitch, V.
AU - Feld, M.
AU - Bunnett, N. W.
AU - Steinhoff, M.
N1 - Funding Information:
This work was supported by grants from the Federal Ministry of Education and Research (DFG STE 1014/2–1, SFB 293 [A14]; SFB 492 [B13]); Interdisziplinäres Zentrum für Klinische Forschung (IZKF) Münster, Project (Stei2/027/06); Rosacea Foundation (USA); and Galderma (France) (to M.S.). V.S. gratefully acknowledges Claudia Mylnikova for invaluable support and inspiration.
PY - 2007/12
Y1 - 2007/12
N2 - Protease-activated receptors (PARs) belong to a family of G protein-coupled receptors activated by serine proteases via proteolytic cleavage. PARs are expressed on epithelial cells, endothelial cells, and leukocytes, indicating a role in controlling barrier function against external danger. During inflammation, microorganisms as well as host immune cells release various proteases activating PARs. Thus, PARs can be viewed as an integral component of the host antimicrobial alarm system. When stimulated, PARs regulate various functions of leukocytes in vivo and in vitro, revealing a novel pathway by which proteases affect innate immune responses. Understanding protease-immune interactions could lead to novel strategies for the treatment of infectious and immune-related diseases.
AB - Protease-activated receptors (PARs) belong to a family of G protein-coupled receptors activated by serine proteases via proteolytic cleavage. PARs are expressed on epithelial cells, endothelial cells, and leukocytes, indicating a role in controlling barrier function against external danger. During inflammation, microorganisms as well as host immune cells release various proteases activating PARs. Thus, PARs can be viewed as an integral component of the host antimicrobial alarm system. When stimulated, PARs regulate various functions of leukocytes in vivo and in vitro, revealing a novel pathway by which proteases affect innate immune responses. Understanding protease-immune interactions could lead to novel strategies for the treatment of infectious and immune-related diseases.
UR - http://www.scopus.com/inward/record.url?scp=36048945434&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=36048945434&partnerID=8YFLogxK
U2 - 10.1016/j.it.2007.09.001
DO - 10.1016/j.it.2007.09.001
M3 - Review article
C2 - 17977790
AN - SCOPUS:36048945434
SN - 1471-4906
VL - 28
SP - 541
EP - 550
JO - Trends in Immunology
JF - Trends in Immunology
IS - 12
ER -