Protease inhibitor combination therapy and decreased condom use among gay men

Ralph J. DiClemente, Ellen Funkhouser, Gina Wingood, Hala Fawal, Scott D. Holmberg, Sten H. Vermund

Research output: Contribution to journalArticlepeer-review


Background. The objective of the study was to determine whether treatment with protease inhibitors is associated with unprotected sexual behavior. Methods. A total of 592 HIV-infected persons recruited from statewide public clinics in nonurban Alabama communities completed an assessment that, among other variables, elicited information on demographics, current sexual practices, health status, and medication use. Associations of treatment with protease inhibitors and high-risk sexual behavior were estimated, adjusting for potential confounders. Results. Treatment with protease inhibitors was not associated with whether a person was sexually active or with high-risk practices among sexually active heterosexual men and women. Among men who had sex with men, however, treatment with protease inhibitors was associated with never using condoms and with inconsistent use of condoms. Conclusions. Clinicians treating patients with protease inhibitors should consider providing risk-reduction counseling.

Original languageEnglish (US)
Pages (from-to)421-425
Number of pages5
JournalSouthern Medical Journal
Issue number4
StatePublished - 2002

ASJC Scopus subject areas

  • General Medicine


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