Protease-mediated ligation of abiotic oligomers

Barney Yoo, Kent Kirshenbaum

Research output: Contribution to journalArticlepeer-review


We demonstrate that proteases can catalyze the ligation of peptidomimetic oligomers. The enzyme clostripain was used to facilitate the native ligation of N-substituted glycine oligomers, or peptoids. In addition to mediating the efficient condensation of two peptoid fragments, iterative ligation events were also performed, giving rise to concatenation products with molecular weights up to 20 kDa. Efficient ligation of peptoid foldamers may enable the chemical synthesis of biomimetic macromolecules capable of forming complex tertiary structures.

Original languageEnglish (US)
Pages (from-to)17132-17133
Number of pages2
JournalJournal of the American Chemical Society
Issue number49
StatePublished - Dec 14 2005

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry
  • Biochemistry
  • Colloid and Surface Chemistry


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