Protective role of vitamin D against age-related macular degeneration: A hypothesis

Research output: Contribution to journalReview articlepeer-review


Age-related macular degeneration (AMD) is the leading cause of blindness among Americans. Local inflammation is implied in the pathophysiology of AMD that may cause photoreceptor destruction and blindness. Vitamin D may prevent AMD progression via its anti-inflammatory and antiangiogenic properties. Scientific evidence is discussed for the associations of vitamin D (serum, diet, and sunlight) and AMD. Evidence suggests inverse associations between serum vitamin D and its sources (specifically fish), and AMD. Associations with sunlight, hypothesized to increase risk for AMD, have been inconsistent possibly due to protection from vitamin D. Vitamin D may be a new protective factor against AMD.

Original languageEnglish (US)
Pages (from-to)290-301
Number of pages12
JournalTopics in Clinical Nutrition
Issue number4
StatePublished - Oct 2010


  • Age-related macular degeneration
  • fish
  • sunlight
  • vitamin D

ASJC Scopus subject areas

  • Nutrition and Dietetics


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