Protein-Engineered Functional Materials

Yao Wang, Priya Katyal, Jin Kim Montclare

Research output: Contribution to journalReview articlepeer-review


Proteins are versatile macromolecules that can perform a variety of functions. In the past three decades, they have been commonly used as building blocks to generate a range of biomaterials. Owing to their flexibility, proteins can either be used alone or in combination with other functional molecules. Advances in synthetic and chemical biology have enabled new protein fusions as well as the integration of new functional groups leading to biomaterials with emergent properties. This review discusses protein-engineered materials from the perspectives of domain-based designs as well as physical and chemical approaches for crosslinked materials, with special emphasis on the creation of hydrogels. Engineered proteins that organize or template metal ions, bear noncanonical amino acids (NCAAs), and their potential applications, are also reviewed.

Original languageEnglish (US)
Article number1801374
JournalAdvanced Healthcare Materials
Issue number11
StatePublished - Jun 6 2019


  • biomaterials
  • coiled-coils
  • engineered proteins
  • functional materials
  • recombinant protein

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Pharmaceutical Science


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