TY - JOUR
T1 - Protein-protein interaction inhibitors
T2 - Small molecules from screening techniques
AU - Fletcher, Steven
AU - Hamilton, Andrew D.
PY - 2007/5
Y1 - 2007/5
N2 - Protein-protein interactions play crucial roles in a number of biological processes, and, as such, their disruption is becoming an area of intense research. Despite the many challenges associated with the development of protein-protein interaction inhibitors, such as the large and relatively featureless interfacial areas involved, there has been considerable success in recent years. Importantly, through the existence of protein "hot spots", some of this success takes the form of small molecule inhibitors that have been identified from a variety of screening techniques.
AB - Protein-protein interactions play crucial roles in a number of biological processes, and, as such, their disruption is becoming an area of intense research. Despite the many challenges associated with the development of protein-protein interaction inhibitors, such as the large and relatively featureless interfacial areas involved, there has been considerable success in recent years. Importantly, through the existence of protein "hot spots", some of this success takes the form of small molecule inhibitors that have been identified from a variety of screening techniques.
KW - Herpes simplex virus
KW - Interleukin-2
KW - T cell factor
KW - The p53-MDM2 interaction
KW - Thyroid hormone receptor
UR - http://www.scopus.com/inward/record.url?scp=34447290874&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34447290874&partnerID=8YFLogxK
U2 - 10.2174/156802607780906735
DO - 10.2174/156802607780906735
M3 - Review article
C2 - 17508923
AN - SCOPUS:34447290874
SN - 1568-0266
VL - 7
SP - 922
EP - 927
JO - Current topics in medicinal chemistry
JF - Current topics in medicinal chemistry
IS - 10
ER -