Protein-protein interaction inhibitors: Small molecules from screening techniques

Steven Fletcher, Andrew D. Hamilton

Research output: Contribution to journalReview articlepeer-review


Protein-protein interactions play crucial roles in a number of biological processes, and, as such, their disruption is becoming an area of intense research. Despite the many challenges associated with the development of protein-protein interaction inhibitors, such as the large and relatively featureless interfacial areas involved, there has been considerable success in recent years. Importantly, through the existence of protein "hot spots", some of this success takes the form of small molecule inhibitors that have been identified from a variety of screening techniques.

Original languageEnglish (US)
Pages (from-to)922-927
Number of pages6
JournalCurrent topics in medicinal chemistry
Issue number10
StatePublished - May 2007


  • Herpes simplex virus
  • Interleukin-2
  • T cell factor
  • The p53-MDM2 interaction
  • Thyroid hormone receptor

ASJC Scopus subject areas

  • Drug Discovery


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