Protein-protein interactions in transcription: A fertile ground for helix mimetics

Danielle A. Guarracino, Brooke N. Bullock, Paramjit S. Arora

Research output: Contribution to journalArticlepeer-review

Abstract

Designed ligands that inhibit protein-protein interactions involved in gene expression are valuable as reagents for genomics research and as leads for drug discovery efforts. Selective modulation of protein-protein interactions has proven to be a daunting task for synthetic ligands; however, the last decade has seen significant advances in inhibitor design, especially for helical protein interfaces. This review discusses examples of transcriptional complexes targeted by designer helices.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalBiopolymers
Volume95
Issue number1
DOIs
StatePublished - Jan 2011

Keywords

  • Helix mimetics
  • Protein-protein interactions
  • Transcription

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Biomaterials
  • Organic Chemistry

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