Protein-protein interactions in transcription: A fertile ground for helix mimetics

Danielle A. Guarracino, Brooke N. Bullock, Paramjit S. Arora

Research output: Contribution to journalArticlepeer-review


Designed ligands that inhibit protein-protein interactions involved in gene expression are valuable as reagents for genomics research and as leads for drug discovery efforts. Selective modulation of protein-protein interactions has proven to be a daunting task for synthetic ligands; however, the last decade has seen significant advances in inhibitor design, especially for helical protein interfaces. This review discusses examples of transcriptional complexes targeted by designer helices.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
Issue number1
StatePublished - Jan 2011


  • Helix mimetics
  • Protein-protein interactions
  • Transcription

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Biomaterials
  • Organic Chemistry


Dive into the research topics of 'Protein-protein interactions in transcription: A fertile ground for helix mimetics'. Together they form a unique fingerprint.

Cite this