Protein-protein interactions in transcription: A fertile ground for helix mimetics

Danielle A. Guarracino; Brooke N. Bullock; Paramjit S. Arora

doi:10.1002/bip.21546

Protein-protein interactions in transcription: A fertile ground for helix mimetics

Danielle A. Guarracino, Brooke N. Bullock, Paramjit S. Arora

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

Designed ligands that inhibit protein-protein interactions involved in gene expression are valuable as reagents for genomics research and as leads for drug discovery efforts. Selective modulation of protein-protein interactions has proven to be a daunting task for synthetic ligands; however, the last decade has seen significant advances in inhibitor design, especially for helical protein interfaces. This review discusses examples of transcriptional complexes targeted by designer helices.

Original language	English (US)
Pages (from-to)	1-7
Number of pages	7
Journal	Biopolymers
Volume	95
Issue number	1
DOIs	https://doi.org/10.1002/bip.21546
State	Published - Jan 2011

Keywords

Helix mimetics
Protein-protein interactions
Transcription

ASJC Scopus subject areas

Biophysics
Biochemistry
Biomaterials
Organic Chemistry

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10.1002/bip.21546

Cite this

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Protein-protein interactions in transcription: A fertile ground for helix mimetics

Abstract

Keywords

ASJC Scopus subject areas

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