Protein recognition and denaturation by self-assembling fragments on a DNA quadruplex scaffold

Debarati M. Tagore, K. Ingrid Sprinz, Steven Fletcher, Janarthanan Jayawickramarajah, Andrew D. Hamilton

Research output: Contribution to journalArticlepeer-review

Abstract

Recognize this face? Quadruplex DNA has been used as a noncovalent scaffold to project binding groups for protein recognition and denaturation, with the best quadruplex decreasing the melting temperature of cytochrome c by about 45 K. (Figure Presented).

Original languageEnglish (US)
Pages (from-to)223-225
Number of pages3
JournalAngewandte Chemie - International Edition
Volume46
Issue number1-2
DOIs
StatePublished - 2007

Keywords

  • DNA structures
  • Enzymes
  • Self-assembly
  • Supramolecular chemistry
  • Surface recognition

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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