Protein recognition by an ensemble of fluorescent DNA G-quadruplexes

David Margulies, Andrew D. Hamilton

Research output: Contribution to journalArticlepeer-review


Sniffing out proteins: Fluorescent DNA G-quadruplexes have been used for building versatile signaling receptors for proteins in a single solution. Introducing a protein sample to the ensemble results in a unique emission signature for unambiguous identification (see scheme, R=fluorophore). The self-assembled, pattern-based protein detection systems are easily fabricated, have the potential for high-throughput operations, and have the ability to handle small protein samples.

Original languageEnglish (US)
Pages (from-to)1771-1774
Number of pages4
JournalAngewandte Chemie - International Edition
Issue number10
StatePublished - Feb 23 2009


  • DNA
  • Fluorescence
  • Proteins
  • Self-assembly
  • Supramolecular chemistry

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry


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