Protein recognition using synthetic surface-targeted agents

Rishi Jain, Justin T. Ernst, Olaf Kutzki, Soon Park Hyung, Andrew D. Hamilton

Research output: Contribution to journalReview article

Abstract

The design of synthetic agents to disrupt protein-protein interactions has received relatively little attention in recent years. In this review we describe strategies for targeting different types of protein surfaces using mimetics of protein secondary or tertiary structure. In this way strong and selective binding to a protein surface has be achieved and disruption of clinically important protein-protein interactions has been demonstrated in models of human disease.

Original languageEnglish (US)
Pages (from-to)89-100
Number of pages12
JournalMolecular Diversity
Volume8
Issue number2
DOIs
StatePublished - 2004

ASJC Scopus subject areas

  • Catalysis
  • Information Systems
  • Molecular Biology
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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