Protein surface recognition and proteomimetics: Mimics of protein surface structure and function

Steven Fletcher, Andrew D. Hamilton

Research output: Contribution to journalReview article

Abstract

Due to their key roles in a number of biological processes, protein-protein interactions are attractive and important targets, typically involving areas greater than 6 nm2. The disruption of such interactions remains a challenging feat but, in recent years, there has been considerable progress in the design of proteomimetics: molecules that mimic the structure and function of extended regions of protein surfaces. In particular, porphyrins, calixarenes, α-helical mimetics and small molecules have successfully modulated significant protein-protein interactions, including those involved in cancer and HIV.

Original languageEnglish (US)
Pages (from-to)632-638
Number of pages7
JournalCurrent Opinion in Chemical Biology
Volume9
Issue number6
DOIs
StatePublished - Dec 2005

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry

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