TY - JOUR
T1 - Protein surface recognition and proteomimetics
T2 - Mimics of protein surface structure and function
AU - Fletcher, Steven
AU - Hamilton, Andrew D.
PY - 2005/12
Y1 - 2005/12
N2 - Due to their key roles in a number of biological processes, protein-protein interactions are attractive and important targets, typically involving areas greater than 6 nm2. The disruption of such interactions remains a challenging feat but, in recent years, there has been considerable progress in the design of proteomimetics: molecules that mimic the structure and function of extended regions of protein surfaces. In particular, porphyrins, calixarenes, α-helical mimetics and small molecules have successfully modulated significant protein-protein interactions, including those involved in cancer and HIV.
AB - Due to their key roles in a number of biological processes, protein-protein interactions are attractive and important targets, typically involving areas greater than 6 nm2. The disruption of such interactions remains a challenging feat but, in recent years, there has been considerable progress in the design of proteomimetics: molecules that mimic the structure and function of extended regions of protein surfaces. In particular, porphyrins, calixarenes, α-helical mimetics and small molecules have successfully modulated significant protein-protein interactions, including those involved in cancer and HIV.
UR - http://www.scopus.com/inward/record.url?scp=27744564465&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=27744564465&partnerID=8YFLogxK
U2 - 10.1016/j.cbpa.2005.10.006
DO - 10.1016/j.cbpa.2005.10.006
M3 - Review article
C2 - 16242379
AN - SCOPUS:27744564465
SN - 1367-5931
VL - 9
SP - 632
EP - 638
JO - Current Opinion in Chemical Biology
JF - Current Opinion in Chemical Biology
IS - 6
ER -