Protein surface recognition by synthetic receptors based on a tetraphenylporphyrin scaffold

Rishi K. Jain; Andrew D. Hamilton

doi:10.1021/ol005871s

Protein surface recognition by synthetic receptors based on a tetraphenylporphyrin scaffold

Rishi K. Jain, Andrew D. Hamilton

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

(matrix presented) Receptors based on a tetraphenylporphyrin scaffold bearing different charged and hydrophobic groups have been synthesized. The interactions of these with horse heart cytochrome c were studied by fluorescence spectroscopy. Receptor 4 was identified to be the strongest synthetic receptor (K_d = 20 nM) for cytochrome c. The differences in affinity among the receptors reflected a dependence on the number of anionic and hydrophobic groups.

Original language	English (US)
Pages (from-to)	1721-1723
Number of pages	3
Journal	Organic Letters
Volume	2
Issue number	12
DOIs	https://doi.org/10.1021/ol005871s
State	Published - Jun 15 2000

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

Access to Document

10.1021/ol005871s

Cite this

@article{31c096e04e0f40e09125cdd081b552e8,

title = "Protein surface recognition by synthetic receptors based on a tetraphenylporphyrin scaffold",

abstract = "(matrix presented) Receptors based on a tetraphenylporphyrin scaffold bearing different charged and hydrophobic groups have been synthesized. The interactions of these with horse heart cytochrome c were studied by fluorescence spectroscopy. Receptor 4 was identified to be the strongest synthetic receptor (Kd = 20 nM) for cytochrome c. The differences in affinity among the receptors reflected a dependence on the number of anionic and hydrophobic groups.",

author = "Jain, {Rishi K.} and Hamilton, {Andrew D.}",

year = "2000",

month = jun,

day = "15",

doi = "10.1021/ol005871s",

language = "English (US)",

volume = "2",

pages = "1721--1723",

journal = "Organic Letters",

issn = "1523-7060",

publisher = "American Chemical Society",

number = "12",

}

TY - JOUR

T1 - Protein surface recognition by synthetic receptors based on a tetraphenylporphyrin scaffold

AU - Jain, Rishi K.

AU - Hamilton, Andrew D.

PY - 2000/6/15

Y1 - 2000/6/15

N2 - (matrix presented) Receptors based on a tetraphenylporphyrin scaffold bearing different charged and hydrophobic groups have been synthesized. The interactions of these with horse heart cytochrome c were studied by fluorescence spectroscopy. Receptor 4 was identified to be the strongest synthetic receptor (Kd = 20 nM) for cytochrome c. The differences in affinity among the receptors reflected a dependence on the number of anionic and hydrophobic groups.

AB - (matrix presented) Receptors based on a tetraphenylporphyrin scaffold bearing different charged and hydrophobic groups have been synthesized. The interactions of these with horse heart cytochrome c were studied by fluorescence spectroscopy. Receptor 4 was identified to be the strongest synthetic receptor (Kd = 20 nM) for cytochrome c. The differences in affinity among the receptors reflected a dependence on the number of anionic and hydrophobic groups.

UR - http://www.scopus.com/inward/record.url?scp=0034658869&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034658869&partnerID=8YFLogxK

U2 - 10.1021/ol005871s

DO - 10.1021/ol005871s

M3 - Article

C2 - 10880210

AN - SCOPUS:0034658869

SN - 1523-7060

VL - 2

SP - 1721

EP - 1723

JO - Organic Letters

JF - Organic Letters

IS - 12

ER -

Protein surface recognition by synthetic receptors based on a tetraphenylporphyrin scaffold

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this