Proteinase-activated receptors: New functions for old enzymes

Stephan K. Böhm; Karen McConalogue; Wuyi Kong; Nigel W. Bunnett

doi:10.1152/physiologyonline.1998.13.5.231

Proteinase-activated receptors: New functions for old enzymes

Stephan K. Böhm, Karen McConalogue, Wuyi Kong, Nigel W. Bunnett

Molecular Pathobiology

Research output: Contribution to journal › Article › peer-review

Abstract

Although proteases are traditionally viewed as degradative enzymes, characterization of a family of G protein-coupled receptors that are activated by proteolysis reveals a new role. Certain proteases function as signaling molecules that specifically regulate cells by cleaving and activating a family of proteinase-activated receptors.

Original language	English (US)
Pages (from-to)	231-240
Number of pages	10
Journal	News in Physiological Sciences
Volume	13
Issue number	5
DOIs	https://doi.org/10.1152/physiologyonline.1998.13.5.231
State	Published - Oct 1998

ASJC Scopus subject areas

Physiology

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10.1152/physiologyonline.1998.13.5.231

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title = "Proteinase-activated receptors: New functions for old enzymes",

abstract = "Although proteases are traditionally viewed as degradative enzymes, characterization of a family of G protein-coupled receptors that are activated by proteolysis reveals a new role. Certain proteases function as signaling molecules that specifically regulate cells by cleaving and activating a family of proteinase-activated receptors.",

author = "B{\"o}hm, {Stephan K.} and Karen McConalogue and Wuyi Kong and Bunnett, {Nigel W.}",

year = "1998",

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Y1 - 1998/10

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AB - Although proteases are traditionally viewed as degradative enzymes, characterization of a family of G protein-coupled receptors that are activated by proteolysis reveals a new role. Certain proteases function as signaling molecules that specifically regulate cells by cleaving and activating a family of proteinase-activated receptors.

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Proteinase-activated receptors: New functions for old enzymes

Abstract

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