Prototyping Nanorod Control: A DNA Double Helix Sheathed within a DNA Six-Helix Bundle

Risheng Wang, Wenyan Liu, Nadrian C. Seeman

Research output: Contribution to journalArticlepeer-review


The control of the structure of matter is a key goal of nanoscience. DNA is an exciting molecule for control because it forms programmable intermolecular interactions. Stiff DNA structures, such as the double crossover motif, the tensegrity triangle, and the six-helix bundle (6HB) have been used to produce periodic arrays of DNA components. The 6HB motif consists of six DNA double helices flanking an inner cavity whose diameter is similar to that of a double helix. This motif appears to be an excellent candidate to sheathe and control nanorods by inserting them into the cavity, and then to control the placement and orientation of the rod by controlling the DNA sheath. Here, we prototype this kind of control by using a seventh DNA double helix as the nanorod and fixing it inside the 6HB motif.

Original languageEnglish (US)
Pages (from-to)862-867
Number of pages6
JournalChemistry and Biology
Issue number8
StatePublished - Aug 28 2009


  • DNA

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry


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