Pyramidal Neurons Grow Up and Change Their Mind

Gord Fishell; Carina Hanashima

doi:10.1016/j.neuron.2008.01.018

Pyramidal Neurons Grow Up and Change Their Mind

Gord Fishell, Carina Hanashima

Center for Genomics and Systems Biology

Research output: Contribution to journal › Short survey › peer-review

Abstract

The precise stereotypic projections of pyramidal neurons within the six-layered cortex of mammals are key in allowing this structure to attain its high level of function. Recent studies have provided the first indications that postmitotic transcription factors are required for the formation and maintenance of both corticofugal and intracortical pyramidal cell populations. Here, we discuss these new findings in the context of our present understanding of cortical cell specification.

Original language	English (US)
Pages (from-to)	333-338
Number of pages	6
Journal	Neuron
Volume	57
Issue number	3
DOIs	https://doi.org/10.1016/j.neuron.2008.01.018
State	Published - Feb 7 2008

ASJC Scopus subject areas

General Neuroscience

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10.1016/j.neuron.2008.01.018

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title = "Pyramidal Neurons Grow Up and Change Their Mind",

abstract = "The precise stereotypic projections of pyramidal neurons within the six-layered cortex of mammals are key in allowing this structure to attain its high level of function. Recent studies have provided the first indications that postmitotic transcription factors are required for the formation and maintenance of both corticofugal and intracortical pyramidal cell populations. Here, we discuss these new findings in the context of our present understanding of cortical cell specification.",

author = "Gord Fishell and Carina Hanashima",

note = "Funding Information: We would like to thank all members of the Fishell laboratory and Wataru Ochiai of the Hanashima laboratory for their many helpful comments. We would particularly like to thank Jeremy Dasen, Elsa Rossignol, Renata Batista-Brito, Jens Hjerling Leffler, and Robert Machold, who all critically read drafts of this manuscript and provided numerous helpful suggestions. G.F. is supported by generous support from both the NIH and the Simons Foundation.",

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N2 - The precise stereotypic projections of pyramidal neurons within the six-layered cortex of mammals are key in allowing this structure to attain its high level of function. Recent studies have provided the first indications that postmitotic transcription factors are required for the formation and maintenance of both corticofugal and intracortical pyramidal cell populations. Here, we discuss these new findings in the context of our present understanding of cortical cell specification.

AB - The precise stereotypic projections of pyramidal neurons within the six-layered cortex of mammals are key in allowing this structure to attain its high level of function. Recent studies have provided the first indications that postmitotic transcription factors are required for the formation and maintenance of both corticofugal and intracortical pyramidal cell populations. Here, we discuss these new findings in the context of our present understanding of cortical cell specification.

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Pyramidal Neurons Grow Up and Change Their Mind

Abstract

ASJC Scopus subject areas

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