Quality of life and physical functioning in black and white adults with hypertrophic cardiomyopathy

Milla Arabadjian, Gary Yu, Allison Vorderstrasse, Mark V. Sherrid, Victoria Vaughan Dickson

Research output: Contribution to journalArticlepeer-review


Background: Hypertrophic cardiomyopathy (HCM) is a common and clinically heterogeneous inherited cardiac disease. Quality of life (QOL) and physical functioning are important clinically but are underexplored in diverse populations with HCM. Objectives: To examine predictors for and compare QOL and physical functioning in Black and White adults with HCM. Methods: We analyzed a sub-sample from a longitudinal prospective study on HCM. Eligibility criteria included self-identified Black and White adults (≥18 years) with clinical HCM. QOL was measured with the Minnesota Living with Heart Failure Questionnaire (MLWHF);physical functioning included age-adjusted exercise capacity and NYHA class. Covariates included HCM structural characteristics and common comorbidities. We analyzed data from 434 individuals, 57 (13.1%) of whom self-identified as Black/African American. Results: In this sample, the Black cohort had higher MLWHF scores, 31.2 (27.2) v. 23.9 (22.1), p=0.042, signifying worse QOL, but there were no intergroup differences when QOL was dichotomized. Mean metabolic equivalents (METs) on symptom-limited stress testing were similar, though the Black cohort was younger, 54.6 (13.4) v.62.5 (14.8) years, p=0.001. No one from the Black cohort achieved an “excellent-for-age” exercise capacity, and 64.1% had a “below-average-for-age” exercise capacity vs 47% in the White cohort, though this was not statistically significant, p=0.058. There was no difference between groups in advanced NYHA class. Female gender was associated with worse QOL and physical functioning irrespective of covariates. Conclusions: This study is a starting point that underscores the need for a more comprehensive examination of well-being and physical functioning in Black populations with HCM.

Original languageEnglish (US)
Pages (from-to)142-147
Number of pages6
JournalHeart and Lung
StatePublished - Nov 1 2022


  • Black/African American
  • Exercise capacity
  • Hypertrophic cardiomyopathy
  • Quality of life

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine


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