Quantifying gene expression: the importance of being subtle

Gustavo Monteiro Silva; Christine Vogel

doi:10.15252/msb.20167325

Quantifying gene expression: the importance of being subtle

Gustavo Monteiro Silva, Christine Vogel

Biology and Genomics

Research output: Contribution to journal › Article › peer-review

Abstract

Gene expression is regulated at both the mRNA and protein level through on-off switches and fine-tuned control. In their recent study, Edfors et al (2016) use highly accurate, targeted proteomics methods and examine to what extent the amount of protein produced per mRNA transcript varies across different tissues. They find that the bulk part of protein concentrations is set at a per-gene level: This relationship, the protein/mRNA ratio, is constant across cell types and tissues, but varies by several orders of magnitude across genes.

Original language	English (US)
Article number	885
Journal	Molecular systems biology
Volume	12
Issue number	10
DOIs	https://doi.org/10.15252/msb.20167325
State	Published - Oct 1 2016

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
General Immunology and Microbiology
General Agricultural and Biological Sciences
Applied Mathematics

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Quantifying gene expression: the importance of being subtle

Abstract

ASJC Scopus subject areas

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