Quantifying gene expression: the importance of being subtle

Gustavo Monteiro Silva, Christine Vogel

Research output: Contribution to journalArticlepeer-review


Gene expression is regulated at both the mRNA and protein level through on-off switches and fine-tuned control. In their recent study, Edfors et al (2016) use highly accurate, targeted proteomics methods and examine to what extent the amount of protein produced per mRNA transcript varies across different tissues. They find that the bulk part of protein concentrations is set at a per-gene level: This relationship, the protein/mRNA ratio, is constant across cell types and tissues, but varies by several orders of magnitude across genes.

Original languageEnglish (US)
Article number885
JournalMolecular systems biology
Issue number10
StatePublished - Oct 1 2016

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology
  • General Immunology and Microbiology
  • General Agricultural and Biological Sciences
  • Applied Mathematics


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