Quantitative analysis of muscle atrophy under hyperglycemic conditions using C. Elegans model in a scalable microfluidic device

Samuel Sofela, Ajymurat Orozaliev, Sarah Sahloul, Nandita Chaturvedi, Davood Shahjerdi, Yong Ak Song

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In this study, we propose a unique behavioral response adaptive design of elastomeric micropillars to quantify the muscle force of partially immobilized worms. Our design approach stems out of the need to eliminate the complexities involved in tracking free-moving worms and its coiling behavior as well as to fabricate a scalable device for all four stages (larval and adult) of C. elegans. Application of our device to hyperglycemic C. elegans allowed to quantify the muscle force atrophy with varying concentrations of glucose.

Original languageEnglish (US)
Title of host publication22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
PublisherChemical and Biological Microsystems Society
Pages122-125
Number of pages4
ISBN (Electronic)9781510897571
StatePublished - Jan 1 2018
Event22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018 - Kaohsiung, Taiwan, Province of China
Duration: Nov 11 2018Nov 15 2018

Publication series

Name22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
Volume1

Conference

Conference22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
CountryTaiwan, Province of China
CityKaohsiung
Period11/11/1811/15/18

Keywords

  • C. elegans
  • High-throughput drug screening
  • Micropillars
  • Muscle force

ASJC Scopus subject areas

  • Chemistry(all)
  • Bioengineering
  • Chemical Engineering (miscellaneous)
  • Control and Systems Engineering

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