@inproceedings{3948ca60975c481c96adb46bc9b53da8,
title = "Quantitative analysis of muscle atrophy under hyperglycemic conditions using C. Elegans model in a scalable microfluidic device",
abstract = "In this study, we propose a unique behavioral response adaptive design of elastomeric micropillars to quantify the muscle force of partially immobilized worms. Our design approach stems out of the need to eliminate the complexities involved in tracking free-moving worms and its coiling behavior as well as to fabricate a scalable device for all four stages (larval and adult) of C. elegans. Application of our device to hyperglycemic C. elegans allowed to quantify the muscle force atrophy with varying concentrations of glucose.",
keywords = "C. elegans, High-throughput drug screening, Micropillars, Muscle force",
author = "Samuel Sofela and Ajymurat Orozaliev and Sarah Sahloul and Nandita Chaturvedi and Davood Shahjerdi and Song, {Yong Ak}",
year = "2018",
month = jan,
day = "1",
language = "English (US)",
series = "22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018",
publisher = "Chemical and Biological Microsystems Society",
pages = "122--125",
booktitle = "22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018",
note = "22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018 ; Conference date: 11-11-2018 Through 15-11-2018",
}