TY - JOUR
T1 - Quantitative Modeling in Cell Biology
T2 - What Is It Good for?
AU - Mogilner, Alex
AU - Wollman, Roy
AU - Marshall, Wallace F.
N1 - Funding Information:
This work was funded by grants from the NIH (NIGMS GM068952-01 and NIGMS U54 GM64346) and the NSF (DMS 0315782) to A.M., a grant from the NSF (MCB 0416310) to W.F.M., and a University of California Systemwide Biotechnology Research & Education Program GREAT Training Grant (2006-03) to R.W. We are grateful to anonymous reviewers for insightful suggestions.
PY - 2006/9
Y1 - 2006/9
N2 - Recently, there has been a surge in the number of pioneering studies combining experiments with quantitative modeling to explain both relatively simple modules of molecular machinery of the cell and to achieve system-level understanding of cellular networks. Here we discuss the utility and methods of modeling and review several current models of cell signaling, cytoskeletal self-organization, nuclear transport, and the cell cycle. We discuss successes of and barriers to modeling in cell biology and its future directions, and we argue, using the field of bacterial chemotaxis as an example, that the closer the complete systematic understanding of cell behavior is, the more important modeling becomes and the more experiment and theory merge.
AB - Recently, there has been a surge in the number of pioneering studies combining experiments with quantitative modeling to explain both relatively simple modules of molecular machinery of the cell and to achieve system-level understanding of cellular networks. Here we discuss the utility and methods of modeling and review several current models of cell signaling, cytoskeletal self-organization, nuclear transport, and the cell cycle. We discuss successes of and barriers to modeling in cell biology and its future directions, and we argue, using the field of bacterial chemotaxis as an example, that the closer the complete systematic understanding of cell behavior is, the more important modeling becomes and the more experiment and theory merge.
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U2 - 10.1016/j.devcel.2006.08.004
DO - 10.1016/j.devcel.2006.08.004
M3 - Review article
C2 - 16950120
AN - SCOPUS:33747830489
SN - 1534-5807
VL - 11
SP - 279
EP - 287
JO - Developmental Cell
JF - Developmental Cell
IS - 3
ER -