R TPPM: Towards improving solid-state NMR two-pulse phase-modulation heteronuclear dipolar decoupling sequence by refocusing

Asif Equbal; Subhradip Paul; Venus Singh Mithu; Joachim M. Vinther; Niels Chr Nielsen; P. K. Madhu

doi:10.1016/j.jmr.2014.04.009

R TPPM: Towards improving solid-state NMR two-pulse phase-modulation heteronuclear dipolar decoupling sequence by refocusing

Asif Equbal, Subhradip Paul, Venus Singh Mithu, Joachim M. Vinther, Niels Chr Nielsen, P. K. Madhu

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

We present here a simple refocused modification, r TPPM, of the Two-Pulse Phase-Modulation (TPPM) heteronuclear decoupling method, which improves decoupling and makes the sequence much more robust with respect to essential experimental parameters. The modified sequence is compared with the established TPPM sequence and a variety of other decoupling sequences at low to moderate magic-angle spinning frequencies. Simulations are shown to compare TPPM and r TPPM with respect to various experimental parameters. The observations from simulations are corroborated with experimental findings at two spinning frequencies on U-¹³C-glycine and U-¹³C-L-histidine.HCl. ^H2O.

Original language	English (US)
Pages (from-to)	68-73
Number of pages	6
Journal	Journal of Magnetic Resonance
Volume	244
DOIs	https://doi.org/10.1016/j.jmr.2014.04.009
State	Published - Jul 2014

Keywords

Heteronuclear dipolar decoupling
Magic-angle spinning
r TPPM
Solid-state NMR
SPINAL
TPPM

ASJC Scopus subject areas

Biophysics
Biochemistry
Nuclear and High Energy Physics
Condensed Matter Physics

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10.1016/j.jmr.2014.04.009

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title = "R TPPM: Towards improving solid-state NMR two-pulse phase-modulation heteronuclear dipolar decoupling sequence by refocusing",

abstract = "We present here a simple refocused modification, r TPPM, of the Two-Pulse Phase-Modulation (TPPM) heteronuclear decoupling method, which improves decoupling and makes the sequence much more robust with respect to essential experimental parameters. The modified sequence is compared with the established TPPM sequence and a variety of other decoupling sequences at low to moderate magic-angle spinning frequencies. Simulations are shown to compare TPPM and r TPPM with respect to various experimental parameters. The observations from simulations are corroborated with experimental findings at two spinning frequencies on U-13C-glycine and U-13C-L-histidine.HCl. H2O.",

keywords = "Heteronuclear dipolar decoupling, Magic-angle spinning, r TPPM, Solid-state NMR, SPINAL, TPPM",

author = "Asif Equbal and Subhradip Paul and Mithu, {Venus Singh} and Vinther, {Joachim M.} and Nielsen, {Niels Chr} and Madhu, {P. K.}",

note = "Funding Information: We acknowledge the National Facility for High Field NMR, TIFR, Mumbai, and technical assistance of M.V. Naik. The project was supported by a Grant from the Danish National Research Foundation (DNRF59). We also acknowledge the European Commission under the Seventh Framework Programme (FP7), contract Bio-NMR 261863.",

year = "2014",

month = jul,

doi = "10.1016/j.jmr.2014.04.009",

language = "English (US)",

volume = "244",

pages = "68--73",

journal = "Journal of Magnetic Resonance",

issn = "1090-7807",

publisher = "Academic Press Inc.",

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TY - JOUR

T1 - R TPPM

T2 - Towards improving solid-state NMR two-pulse phase-modulation heteronuclear dipolar decoupling sequence by refocusing

AU - Equbal, Asif

AU - Paul, Subhradip

AU - Mithu, Venus Singh

AU - Vinther, Joachim M.

AU - Nielsen, Niels Chr

AU - Madhu, P. K.

N1 - Funding Information: We acknowledge the National Facility for High Field NMR, TIFR, Mumbai, and technical assistance of M.V. Naik. The project was supported by a Grant from the Danish National Research Foundation (DNRF59). We also acknowledge the European Commission under the Seventh Framework Programme (FP7), contract Bio-NMR 261863.

PY - 2014/7

Y1 - 2014/7

N2 - We present here a simple refocused modification, r TPPM, of the Two-Pulse Phase-Modulation (TPPM) heteronuclear decoupling method, which improves decoupling and makes the sequence much more robust with respect to essential experimental parameters. The modified sequence is compared with the established TPPM sequence and a variety of other decoupling sequences at low to moderate magic-angle spinning frequencies. Simulations are shown to compare TPPM and r TPPM with respect to various experimental parameters. The observations from simulations are corroborated with experimental findings at two spinning frequencies on U-13C-glycine and U-13C-L-histidine.HCl. H2O.

AB - We present here a simple refocused modification, r TPPM, of the Two-Pulse Phase-Modulation (TPPM) heteronuclear decoupling method, which improves decoupling and makes the sequence much more robust with respect to essential experimental parameters. The modified sequence is compared with the established TPPM sequence and a variety of other decoupling sequences at low to moderate magic-angle spinning frequencies. Simulations are shown to compare TPPM and r TPPM with respect to various experimental parameters. The observations from simulations are corroborated with experimental findings at two spinning frequencies on U-13C-glycine and U-13C-L-histidine.HCl. H2O.

KW - Heteronuclear dipolar decoupling

KW - Magic-angle spinning

KW - r TPPM

KW - Solid-state NMR

KW - SPINAL

KW - TPPM

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AN - SCOPUS:84901611012

SN - 1090-7807

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SP - 68

EP - 73

JO - Journal of Magnetic Resonance

JF - Journal of Magnetic Resonance

ER -

R TPPM: Towards improving solid-state NMR two-pulse phase-modulation heteronuclear dipolar decoupling sequence by refocusing

Abstract

Keywords

ASJC Scopus subject areas

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