Radial glia serve as neuronal progenitors in all regions of the central nervous system

Todd E. Anthony, Corinna Klein, Gord Fishell, Nathaniel Heintz

Research output: Contribution to journalArticle

Abstract

Radial glial cells function during CNS development as neural progenitors, although their precise contribution to neurogenesis remains controversial. Recent work has argued that regional differences may exist regarding the neurogenic potential of radial glia. Here, we show that the vast majority of neurons in all brain regions derive from radial glia. Cre/loxP fate mapping and clonal analysis demonstrate that radial glia throughout the CNS serve as neuronal progenitors and that radial glia within different regions of the CNS pass through their neurogenic stage of development at distinct time points. Thus, radial glial populations within different CNS regions are not heterogeneous with regard to their potential to generate neurons versus glia.

Original languageEnglish (US)
Pages (from-to)881-890
Number of pages10
JournalNeuron
Volume41
Issue number6
DOIs
StatePublished - Mar 25 2004

ASJC Scopus subject areas

  • Neuroscience(all)

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