Abstract
Objective: The aim of this study was to examine effects of radiation therapy (RT) for head and neck cancer (HNC) on periodontal disease and relationships to caries. Study Design: A multicenter prospective observational cohort study (OraRad) was conducted in patients undergoing RT for HNC. Assessments were conducted by calibrated examiners at the pre-RT (baseline) visit (n = 533), the 12-month visit (n = 414), and the 24-month visit (n = 365). Results: The average whole mouth mean (standard error (SE)) distance from the cementoenamel junction to the gingival margin (CEJ-GM) decreased significantly from 0.43 (0.04) mm at baseline to 0.24 (0.04) mm at 12 months and 0.11 (0.04) mm at 24 months (P ≤.001). Whole mouth mean (SE) percentage of sites with CEJ-GM distance of <0 mm increased significantly from 23.3% (1.0%) at baseline to 28.5% (1.0%) at 12 months and 30.5% (1.1%) at 24 months (P ≤.02). Higher mean radiation dose to the mandible was associated with a greater increase in the percentage of mandibular sites with CEJ-GM distance of <0 mm (P =.003). Both mean CEJ-GM distance and the percentage of sites with a CEJ-GM distance <0 mm were strongly associated with whole mouth mean proportion of decayed, missing, and filled surfaces, as well as proportion of decayed or filled facial/buccal surfaces specifically, (P <.001), with greater gingival recession associated with increased caries. Conclusions: RT for HNC leads to mandibular gingival recession in a dose-dependent manner. This gingival recession may contribute to increased risk for cervical caries seen in these patients.
Original language | English (US) |
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Pages (from-to) | 539-546 |
Number of pages | 8 |
Journal | Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology |
Volume | 133 |
Issue number | 5 |
DOIs | |
State | Published - May 2022 |
Keywords
- Dental Caries/etiology
- Gingival Recession/etiology
- Head and Neck Neoplasms/radiotherapy
- Humans
- Prospective Studies
- Tooth Cervix
ASJC Scopus subject areas
- Oral Surgery
- Radiology Nuclear Medicine and imaging
- Dentistry (miscellaneous)
- Surgery
- Pathology and Forensic Medicine