Random walks in the space of conformations of toy proteins

Rose Du, Alexander Yu Grosberg, Toyoichi Tanaka

    Research output: Contribution to journalArticle

    Abstract

    Monte Carlo dynamics of the lattice toy protein of 48 monomers is interpreted as a random walk in an abstract (discrete) space of conformations. To test the geometry of this space, we examine the return probability P(T), which is the probability to find the polymer in the native state after T Monte Carlo steps, provided that it starts from the native state at the initial moment. Comparing computational data with the theoretical expressions for P(T) for random walks in a variety of different spaces, we show that conformation spaces of polymer loops may have nontrivial dimensions and exhibit negative curvature characteristics of Lobachevskii (hyperbolic) geometry.

    Original languageEnglish (US)
    Pages (from-to)1828-1831
    Number of pages4
    JournalPhysical Review Letters
    Volume84
    Issue number8
    DOIs
    StatePublished - 2000

    ASJC Scopus subject areas

    • Physics and Astronomy(all)

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