Rapid analysis of streaming platelet images by semi-unsupervised learning

Ziji Zhang, Peng Zhang, Peineng Wang, Jawaad Sheriff, Danny Bluestein, Yuefan Deng

Research output: Contribution to journalArticlepeer-review


We developed a fast and accurate deep learning approach employing a semi-unsupervised learning system (SULS) for capturing the real-time noisy, sparse, and ambiguous images of platelet activation. Outperforming several leading supervised learning methods when applied to segment various platelet morphologies, the SULS detects their complex boundaries at submicron resolutions and it massively decreases to only a few hours for segmenting streaming images of 45 million platelets that would have taken 40 years to annotate manually. For the first time, the fast dynamics of pseudopod formation and platelet morphological changes including membrane tethers and transient tethering to vessels are accurately captured.

Original languageEnglish (US)
Article number101895
JournalComputerized Medical Imaging and Graphics
StatePublished - Apr 2021


  • Deep learning
  • Medical imaging
  • Platelets
  • Segmentation

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Computer Vision and Pattern Recognition
  • Health Informatics
  • Computer Graphics and Computer-Aided Design


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