Rapid and label-free optical discrimination of healthy and spiked urine samples

Muhammedin Deliorman, Roaa Alnemari, Mohammad A. Qasaimeh

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The presence of prostate cancer cells in urine samples of cancer patients could be utilized as biomarker for early cancer detection. In this work, the UV absorption spectra of PC3 prostate cancer cells spiked in healthy urine were studied towards development of rapid, label-free, and non-invasive technology to optically detect their presence in patients' urine samples. A comparison of UV absorption spectra of PC3, MCF-7, and HeLa cells revealed that PC3 cells have distinctive peak characteristic at ∼204-206 nm with a wide shoulder in ∼260-290 nm region. Distinctive optical differences were also exhibited between PC3 cells and pelleted urinary cells.

Original languageEnglish (US)
Title of host publication22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
PublisherChemical and Biological Microsystems Society
Pages2449-2450
Number of pages2
ISBN (Electronic)9781510897571
StatePublished - Jan 1 2018
Event22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018 - Kaohsiung, Taiwan, Province of China
Duration: Nov 11 2018Nov 15 2018

Publication series

Name22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
Volume4

Conference

Conference22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
CountryTaiwan, Province of China
CityKaohsiung
Period11/11/1811/15/18

Keywords

  • Cancer detection
  • Optical absorption
  • Prostate cancer cells
  • Ultraviolet fluorescence
  • Urine

ASJC Scopus subject areas

  • Chemistry(all)
  • Bioengineering
  • Chemical Engineering (miscellaneous)
  • Control and Systems Engineering

Fingerprint Dive into the research topics of 'Rapid and label-free optical discrimination of healthy and spiked urine samples'. Together they form a unique fingerprint.

Cite this