TY - GEN
T1 - Rapid detection and trapping of extracellular vesicles by electrokinetic preconcentration for liquid biopsy
AU - Cheung, Lucia
AU - Sahloul, Sarah
AU - Orozaliev, Ajymurat
AU - Song, Yong Ak
N1 - Funding Information:
We gratefully acknowledge the financial support from New York University Abu Dhabi (NYUAD) through the NYUAD Research Enhancement Fund and ADEK (Abu Dhabi Education Council) Award for Research Excellence 2015 (Award number: AARE-073). We would like to thank Renu Pasricha, Research Instrumentation Specialist for Electron Microscopy, for her training and support on using the Transmission Electron Microscopy. The device fabrication was conducted in the microfabrication core facility of NYUAD.
Publisher Copyright:
Copyright © (2018) by Chemical and Biological Microsystems Society. All rights reserved.
PY - 2018
Y1 - 2018
N2 - Extracellular vesicles (EVs) such as exosomes have gained immense research interest in liquid biopsy since their proteomic and genetic contents could potentially be used for early cancer diagnostics as well as for continuous monitoring during treatment. Due to their small sizes and inefficient isolation, however, detection of exosomes in body fluids that are limited in volume such as cerebrospinal fluids still remains a challenge. We have developed an electrokinetic preconcentrator chip in PDMS that can preconcentrate and trap EVs based on ion concentration polarization (ICP). It allows for a sensitive and rapid detection of EVs on chip.
AB - Extracellular vesicles (EVs) such as exosomes have gained immense research interest in liquid biopsy since their proteomic and genetic contents could potentially be used for early cancer diagnostics as well as for continuous monitoring during treatment. Due to their small sizes and inefficient isolation, however, detection of exosomes in body fluids that are limited in volume such as cerebrospinal fluids still remains a challenge. We have developed an electrokinetic preconcentrator chip in PDMS that can preconcentrate and trap EVs based on ion concentration polarization (ICP). It allows for a sensitive and rapid detection of EVs on chip.
KW - Exosomes
KW - Extracellular vesicles
KW - Ion concentration polarization
KW - Liquid biopsy
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M3 - Conference contribution
AN - SCOPUS:85079801102
T3 - 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
SP - 1413
EP - 1416
BT - 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
PB - Chemical and Biological Microsystems Society
T2 - 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
Y2 - 11 November 2018 through 15 November 2018
ER -