Rapid detection and trapping of extracellular vesicles by electrokinetic preconcentration for liquid biopsy

Lucia Cheung, Sarah Sahloul, Ajymurat Orozaliev, Yong Ak Song

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Extracellular vesicles (EVs) such as exosomes have gained immense research interest in liquid biopsy since their proteomic and genetic contents could potentially be used for early cancer diagnostics as well as for continuous monitoring during treatment. Due to their small sizes and inefficient isolation, however, detection of exosomes in body fluids that are limited in volume such as cerebrospinal fluids still remains a challenge. We have developed an electrokinetic preconcentrator chip in PDMS that can preconcentrate and trap EVs based on ion concentration polarization (ICP). It allows for a sensitive and rapid detection of EVs on chip.

Original languageEnglish (US)
Title of host publication22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
PublisherChemical and Biological Microsystems Society
Pages1413-1416
Number of pages4
ISBN (Electronic)9781510897571
StatePublished - 2018
Event22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018 - Kaohsiung, Taiwan, Province of China
Duration: Nov 11 2018Nov 15 2018

Publication series

Name22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
Volume3

Conference

Conference22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
CountryTaiwan, Province of China
CityKaohsiung
Period11/11/1811/15/18

Keywords

  • Exosomes
  • Extracellular vesicles
  • Ion concentration polarization
  • Liquid biopsy

ASJC Scopus subject areas

  • Chemistry(all)
  • Bioengineering
  • Chemical Engineering (miscellaneous)
  • Control and Systems Engineering

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  • Cite this

    Cheung, L., Sahloul, S., Orozaliev, A., & Song, Y. A. (2018). Rapid detection and trapping of extracellular vesicles by electrokinetic preconcentration for liquid biopsy. In 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018 (pp. 1413-1416). (22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018; Vol. 3). Chemical and Biological Microsystems Society.