Rapid prototyping of microfluidic probes for biomedical applications

Ayoola T. Brimmo, Roaa Alnemari, Mohammad A. Qasaimeh

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The microfluidic probe (MFP) is an open space microfluidic device that combines the concepts of hydrodynamic flow confinement (HFC) and scanning probes to overcome the closed channel restrictions of conventional microfluidic devices. In biology, this allows for analysis of mammalian cells, neurons and tissue samples that are otherwise difficult to culture in conventional microfluidic devices. In this paper, we demonstrate how 3-D printing can be used to expedite the design-test cycle of the MFP and hence democratize the concept. The 3D printing procedures were adapted in fabricating the MFPs that were used for all experiments. Characterization of MFP's flow profile footprints are performed by comparisons with numerically calculated profiles. Application of the MFP is then used to selectively label adherent cells cultured in a Petri dish, within their conventional culture environment. Results show that while the 3D printed probes contain some artifacts, they function just as well as MFPs microfabricated using conventional techniques. Overall, this fabrication demonstrates a rapid, easy, and affordable fabrication technique for the MFP.

Original languageEnglish (US)
Title of host publication2018 Advances in Science and Engineering Technology International Conferences, ASET 2018
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages1-4
Number of pages4
ISBN (Electronic)9781538623992
DOIs
StatePublished - Jun 8 2018
Event2018 Advances in Science and Engineering Technology International Conferences, ASET 2018 - Dubai, Sharjah, Abu Dhabi, United Arab Emirates
Duration: Feb 6 2018Apr 5 2018

Publication series

Name2018 Advances in Science and Engineering Technology International Conferences, ASET 2018

Other

Other2018 Advances in Science and Engineering Technology International Conferences, ASET 2018
CountryUnited Arab Emirates
CityDubai, Sharjah, Abu Dhabi
Period2/6/184/5/18

Keywords

  • 3D printing
  • Open space microfluidic
  • cells
  • microfluidic probes

ASJC Scopus subject areas

  • Energy Engineering and Power Technology
  • Renewable Energy, Sustainability and the Environment
  • Civil and Structural Engineering
  • Mechanics of Materials
  • Safety, Risk, Reliability and Quality
  • Waste Management and Disposal
  • Water Science and Technology

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