Rbfox1 Mediates Cell-type-Specific Splicing in Cortical Interneurons

Brie Wamsley; Xavier Hubert Jaglin; Emilia Favuzzi; Giulia Quattrocolo; Maximiliano José Nigro; Nusrath Yusuf; Alireza Khodadadi-Jamayran; Bernardo Rudy; Gord Fishell

doi:10.1016/j.neuron.2018.09.026

Rbfox1 Mediates Cell-type-Specific Splicing in Cortical Interneurons

Brie Wamsley, Xavier Hubert Jaglin, Emilia Favuzzi, Giulia Quattrocolo, Maximiliano José Nigro, Nusrath Yusuf, Alireza Khodadadi-Jamayran, Bernardo Rudy, Gord Fishell

Center for Genomics and Systems Biology

Research output: Contribution to journal › Article › peer-review

Abstract

Wamsley et al. uncover a role of the splicing regulator Rbfox1 in promoting interneuron-specific connectivity in the developing neocortex. By differentially regulating alternative splicing profiles in PV+ and SST+ interneurons, Rbfox1 tailors their efferent connectivity.

Original language	English (US)
Pages (from-to)	846-859.e7
Journal	Neuron
Volume	100
Issue number	4
DOIs	https://doi.org/10.1016/j.neuron.2018.09.026
State	Published - Nov 21 2018

Keywords

ASD
Rbfox1
alternative splicing
connectivity
interneuron
neurodevelopment
synapse

ASJC Scopus subject areas

General Neuroscience

Access to Document

10.1016/j.neuron.2018.09.026

Cite this

@article{300b0bbd6018473994823d8eb17da6a8,

title = "Rbfox1 Mediates Cell-type-Specific Splicing in Cortical Interneurons",

abstract = "Wamsley et al. uncover a role of the splicing regulator Rbfox1 in promoting interneuron-specific connectivity in the developing neocortex. By differentially regulating alternative splicing profiles in PV+ and SST+ interneurons, Rbfox1 tailors their efferent connectivity.",

keywords = "ASD, Rbfox1, alternative splicing, connectivity, interneuron, neurodevelopment, synapse",

author = "Brie Wamsley and Jaglin, {Xavier Hubert} and Emilia Favuzzi and Giulia Quattrocolo and Nigro, {Maximiliano Jos{\'e}} and Nusrath Yusuf and Alireza Khodadadi-Jamayran and Bernardo Rudy and Gord Fishell",

note = "Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",

year = "2018",

month = nov,

day = "21",

doi = "10.1016/j.neuron.2018.09.026",

language = "English (US)",

volume = "100",

pages = "846--859.e7",

journal = "Neuron",

issn = "0896-6273",

publisher = "Cell Press",

number = "4",

}

TY - JOUR

T1 - Rbfox1 Mediates Cell-type-Specific Splicing in Cortical Interneurons

AU - Wamsley, Brie

AU - Jaglin, Xavier Hubert

AU - Favuzzi, Emilia

AU - Quattrocolo, Giulia

AU - Nigro, Maximiliano José

AU - Yusuf, Nusrath

AU - Khodadadi-Jamayran, Alireza

AU - Rudy, Bernardo

AU - Fishell, Gord

PY - 2018/11/21

Y1 - 2018/11/21

N2 - Wamsley et al. uncover a role of the splicing regulator Rbfox1 in promoting interneuron-specific connectivity in the developing neocortex. By differentially regulating alternative splicing profiles in PV+ and SST+ interneurons, Rbfox1 tailors their efferent connectivity.

AB - Wamsley et al. uncover a role of the splicing regulator Rbfox1 in promoting interneuron-specific connectivity in the developing neocortex. By differentially regulating alternative splicing profiles in PV+ and SST+ interneurons, Rbfox1 tailors their efferent connectivity.

KW - ASD

KW - Rbfox1

KW - alternative splicing

KW - connectivity

KW - interneuron

KW - neurodevelopment

KW - synapse

UR - http://www.scopus.com/inward/record.url?scp=85057123825&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85057123825&partnerID=8YFLogxK

U2 - 10.1016/j.neuron.2018.09.026

DO - 10.1016/j.neuron.2018.09.026

M3 - Article

C2 - 30318414

AN - SCOPUS:85057123825

SN - 0896-6273

VL - 100

SP - 846-859.e7

JO - Neuron

JF - Neuron

IS - 4

ER -

Rbfox1 Mediates Cell-type-Specific Splicing in Cortical Interneurons

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this