Rbfox1 Mediates Cell-type-Specific Splicing in Cortical Interneurons

Brie Wamsley, Xavier Hubert Jaglin, Emilia Favuzzi, Giulia Quattrocolo, Maximiliano José Nigro, Nusrath Yusuf, Alireza Khodadadi-Jamayran, Bernardo Rudy, Gord Fishell

Research output: Contribution to journalArticlepeer-review

Abstract

Wamsley et al. uncover a role of the splicing regulator Rbfox1 in promoting interneuron-specific connectivity in the developing neocortex. By differentially regulating alternative splicing profiles in PV+ and SST+ interneurons, Rbfox1 tailors their efferent connectivity.

Original languageEnglish (US)
Pages (from-to)846-859.e7
JournalNeuron
Volume100
Issue number4
DOIs
StatePublished - Nov 21 2018

Keywords

  • ASD
  • Rbfox1
  • alternative splicing
  • connectivity
  • interneuron
  • neurodevelopment
  • synapse

ASJC Scopus subject areas

  • Neuroscience(all)

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