@article{300b0bbd6018473994823d8eb17da6a8,
title = "Rbfox1 Mediates Cell-type-Specific Splicing in Cortical Interneurons",
abstract = "Wamsley et al. uncover a role of the splicing regulator Rbfox1 in promoting interneuron-specific connectivity in the developing neocortex. By differentially regulating alternative splicing profiles in PV+ and SST+ interneurons, Rbfox1 tailors their efferent connectivity.",
keywords = "ASD, Rbfox1, alternative splicing, connectivity, interneuron, neurodevelopment, synapse",
author = "Brie Wamsley and Jaglin, {Xavier Hubert} and Emilia Favuzzi and Giulia Quattrocolo and Nigro, {Maximiliano Jos{\'e}} and Nusrath Yusuf and Alireza Khodadadi-Jamayran and Bernardo Rudy and Gord Fishell",
note = "Funding Information: We thank Prof. Doug Black (UCLA) for the Rbfox1 monoclonal antibody (mAb) and Prof. S{\"u}dhof (Stanford) for the Syt2 Ab. We thank the cores and shared resources of the NYULMC Division of Advanced Research Technologies and their personnel for their technical assistance: Mouse Genotyping Core (Jiali Deng and Jisen Dai); Cytometry and Cell Sorting Core (Kamilah Ryan, Keith Kobylarz, Yulia Chupalova, and Michael Gregory); Genome Technology Center (Yutong Zhang, Olga Aminova, and Adriana Heguy); and Applied Bioinformatics Laboratory (Aristotelis Tsirigos), which is supported in part by grant UL1 TR00038 from the National Center for Advancing Translational Sciences (NCATS), NIH. CCSC and GTC are supported by the Cancer Center Support Grant, P30CA016087, at the Laura and Isaac Perlmutter Cancer Center. We are grateful to Celine Vuong and Doug Black for their comments on the manuscript and to Chia-Ho Lin for her assistance with the iCLIP data analysis. Work in the G.F. lab is supported by the following NIH grants: R01 NS081297; R01 MH071679; R01 MH111529; and P01 NS074972 and by the Simons Foundation (SFARI grant 274578). Work in the B.R. lab is supported by NIH grants: R21NS108447 and P01 NS074972. X.H.J. was supported by EMBO (ALTF 303-2010), HFSP (LT000078/2011-L), the Bettencourt-Schueller Foundation, and by the NIH (K99 MH107684). B.W. was supported by a training grant (NIH, 5T32NS086750), and E.F. was supported by EMBO (ALTF 444-2018). Funding Information: We thank Prof. Doug Black (UCLA) for the Rbfox1 monoclonal antibody (mAb) and Prof. S{\"u}dhof (Stanford) for the Syt2 Ab. We thank the cores and shared resources of the NYULMC Division of Advanced Research Technologies and their personnel for their technical assistance: Mouse Genotyping Core (Jiali Deng and Jisen Dai); Cytometry and Cell Sorting Core (Kamilah Ryan, Keith Kobylarz, Yulia Chupalova, and Michael Gregory); Genome Technology Center (Yutong Zhang, Olga Aminova, and Adriana Heguy); and Applied Bioinformatics Laboratory (Aristotelis Tsirigos), which is supported in part by grant UL1 TR00038 from the National Center for Advancing Translational Sciences (NCATS), NIH . CCSC and GTC are supported by the Cancer Center Support Grant , P30CA016087 , at the Laura and Isaac Perlmutter Cancer Center. We are grateful to Celine Vuong and Doug Black for their comments on the manuscript and to Chia-Ho Lin for her assistance with the iCLIP data analysis. Work in the G.F. lab is supported by the following NIH grants: R01 NS081297 ; R01 MH071679 ; R01 MH111529 ; and P01 NS074972 and by the Simons Foundation (SFARI grant 274578 ). Work in the B.R. lab is supported by NIH grants: R21NS108447 and P01 NS074972 . X.H.J. was supported by EMBO ( ALTF 303-2010 ), HFSP ( LT000078/2011-L ), the Bettencourt-Schueller Foundation , and by the NIH ( K99 MH107684 ). B.W. was supported by a training grant ( NIH , 5T32NS086750 ), and E.F. was supported by EMBO ( ALTF 444-2018 ). Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",
year = "2018",
month = nov,
day = "21",
doi = "10.1016/j.neuron.2018.09.026",
language = "English (US)",
volume = "100",
pages = "846--859.e7",
journal = "Neuron",
issn = "0896-6273",
publisher = "Cell Press",
number = "4",
}