Reaction-diffusion description of biological transport processes in general dimension

W. Nadler, D. L. Stein

    Research output: Contribution to journalArticlepeer-review


    We introduce a reaction-diffusion system capable of modeling ligand migration inside of proteins as well as conformational fluctuations of proteins, and present a detailed analytical and numerical analysis of this system in general dimension. The main observable, the probability of finding the system in the starting state, exhibits dimension-dependent as well as dimension-independent properties, allowing for sharp experimental tests of the effective dimension of the process in question. We discuss the application of this theory to ligand migration in myoglobin and to the description of gating fluctuations of ion channel proteins.

    Original languageEnglish (US)
    Pages (from-to)1918-1936
    Number of pages19
    JournalJournal of Chemical Physics
    Issue number5
    StatePublished - 1996

    ASJC Scopus subject areas

    • General Physics and Astronomy
    • Physical and Theoretical Chemistry


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