Reaction of the octahedral antitumor complex trans-RuCl2(DMSO)4 with 2′deoxyguanosine

Sabina Cauci, Paolo Viglino, Gennaro Esposito, Franco Quadrifoglio

Research output: Contribution to journalArticlepeer-review


The reaction of the antitumor octahedral complex trans-RuCl2(DMSO)4 with 2′deoxyguanosine leads to the reversible formation of two diastereoisomeric monoadducts and one biadduct. This shows that it is possible to accomodate two purine bases in a cis configuration in an octahedral transition metal complex which exhibits antiblastic activity. All the product compounds are characterized by a guanine moiety coordination via the N7 atom. A marked decrease (about two pK units) is observed for the N1H pKa of the coordinated guanine moieties. The reversibility of the monodentate binding could explain the low toxicity of the ruthenium(II) complexes.

Original languageEnglish (US)
Pages (from-to)739-751
Number of pages13
JournalJournal of Inorganic Biochemistry
Issue number4
StatePublished - Sep 1991

ASJC Scopus subject areas

  • Biochemistry
  • Inorganic Chemistry


Dive into the research topics of 'Reaction of the octahedral antitumor complex trans-RuCl2(DMSO)4 with 2′deoxyguanosine'. Together they form a unique fingerprint.

Cite this