Reaction of the octahedral antitumor complex trans-RuCl2(DMSO)4 with 2′deoxyguanosine

Sabina Cauci; Paolo Viglino; Gennaro Esposito; Franco Quadrifoglio

doi:10.1016/0162-0134(91)80045-J

Reaction of the octahedral antitumor complex trans-RuCl₂(DMSO)₄ with 2′deoxyguanosine

Sabina Cauci, Paolo Viglino, Gennaro Esposito, Franco Quadrifoglio

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

The reaction of the antitumor octahedral complex trans-RuCl₂(DMSO)₄ with 2′deoxyguanosine leads to the reversible formation of two diastereoisomeric monoadducts and one biadduct. This shows that it is possible to accomodate two purine bases in a cis configuration in an octahedral transition metal complex which exhibits antiblastic activity. All the product compounds are characterized by a guanine moiety coordination via the N7 atom. A marked decrease (about two pK units) is observed for the N1H pKa of the coordinated guanine moieties. The reversibility of the monodentate binding could explain the low toxicity of the ruthenium(II) complexes.

Original language	English (US)
Pages (from-to)	739-751
Number of pages	13
Journal	Journal of Inorganic Biochemistry
Volume	43
Issue number	4
DOIs	https://doi.org/10.1016/0162-0134(91)80045-J
State	Published - Sep 1991

ASJC Scopus subject areas

Biochemistry
Inorganic Chemistry

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@article{cb0088340d964389a5ec1d8da628ac26,

title = "Reaction of the octahedral antitumor complex trans-RuCl2(DMSO)4 with 2′deoxyguanosine",

abstract = "The reaction of the antitumor octahedral complex trans-RuCl2(DMSO)4 with 2′deoxyguanosine leads to the reversible formation of two diastereoisomeric monoadducts and one biadduct. This shows that it is possible to accomodate two purine bases in a cis configuration in an octahedral transition metal complex which exhibits antiblastic activity. All the product compounds are characterized by a guanine moiety coordination via the N7 atom. A marked decrease (about two pK units) is observed for the N1H pKa of the coordinated guanine moieties. The reversibility of the monodentate binding could explain the low toxicity of the ruthenium(II) complexes.",

author = "Sabina Cauci and Paolo Viglino and Gennaro Esposito and Franco Quadrifoglio",

note = "Funding Information: We thank Professor G. Mestroni and Dr. E. Alessio for usef2 discussions and suggestions. The authors would also like to thank Mr. R. Nardini (C{\textquoteright}.S.L. 7, L/dine, Italy) for the atomic absorption measurements. The work was carried out wirh the ,$nonciai supporr qf Italian MURST and qf CNR (grant No. 89.034X. 141.",

year = "1991",

month = sep,

doi = "10.1016/0162-0134(91)80045-J",

language = "English (US)",

volume = "43",

pages = "739--751",

journal = "Journal of Inorganic Biochemistry",

issn = "0162-0134",

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number = "4",

}

TY - JOUR

T1 - Reaction of the octahedral antitumor complex trans-RuCl2(DMSO)4 with 2′deoxyguanosine

AU - Cauci, Sabina

AU - Viglino, Paolo

AU - Esposito, Gennaro

AU - Quadrifoglio, Franco

N1 - Funding Information: We thank Professor G. Mestroni and Dr. E. Alessio for usef2 discussions and suggestions. The authors would also like to thank Mr. R. Nardini (C’.S.L. 7, L/dine, Italy) for the atomic absorption measurements. The work was carried out wirh the ,$nonciai supporr qf Italian MURST and qf CNR (grant No. 89.034X. 141.

PY - 1991/9

Y1 - 1991/9

N2 - The reaction of the antitumor octahedral complex trans-RuCl2(DMSO)4 with 2′deoxyguanosine leads to the reversible formation of two diastereoisomeric monoadducts and one biadduct. This shows that it is possible to accomodate two purine bases in a cis configuration in an octahedral transition metal complex which exhibits antiblastic activity. All the product compounds are characterized by a guanine moiety coordination via the N7 atom. A marked decrease (about two pK units) is observed for the N1H pKa of the coordinated guanine moieties. The reversibility of the monodentate binding could explain the low toxicity of the ruthenium(II) complexes.

AB - The reaction of the antitumor octahedral complex trans-RuCl2(DMSO)4 with 2′deoxyguanosine leads to the reversible formation of two diastereoisomeric monoadducts and one biadduct. This shows that it is possible to accomodate two purine bases in a cis configuration in an octahedral transition metal complex which exhibits antiblastic activity. All the product compounds are characterized by a guanine moiety coordination via the N7 atom. A marked decrease (about two pK units) is observed for the N1H pKa of the coordinated guanine moieties. The reversibility of the monodentate binding could explain the low toxicity of the ruthenium(II) complexes.

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DO - 10.1016/0162-0134(91)80045-J

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VL - 43

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JO - Journal of Inorganic Biochemistry

JF - Journal of Inorganic Biochemistry

SN - 0162-0134

IS - 4