Reactive Oxygen Species, Synaptic Plasticity, and Memory

Kenneth T. Kishida, Eric Klann

Research output: Chapter in Book/Report/Conference proceedingChapter


Increasing evidence suggests that reactive oxygen species (ROS), such as superoxide and hydrogen peroxide, act as signaling molecules necessary for neuronal processes underlying cognition. Specifically, ROS have been shown to be necessary in molecular processes underlying signal transduction, synaptic plasticity, and memory formation. Research from several laboratories suggests that NADPH oxidase is an important source of superoxide in the brain. Herein we review evidence showing that ROS are important signaling molecules involved in synaptic plasticity and memory formation. Moreover, we will discuss the evidence that a neuronal NADPH oxidase complex is a key regulator of ROS generation in synaptic plasticity and memory formation. Understanding redox signaling in the brain, including the sources and molecular targets of ROS, is important for a full understanding of the signaling pathways that underlie synaptic plasticity and memory. Moreover, knowledge of ROS function in the brain is critical for understanding aging and neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease that may be exacerbated by the unregulated generation of ROS.

Original languageEnglish (US)
Title of host publicationContemporary Clinical Neuroscience
PublisherSpringer Nature
Number of pages27
StatePublished - 2009

Publication series

NameContemporary Clinical Neuroscience
ISSN (Print)2627-535X
ISSN (Electronic)2627-5341


  • Cognition
  • High-frequency stimulation
  • Hippocampus
  • Learning
  • Long-term potentiation
  • Memory
  • NADPH oxidase
  • NMDA receptor
  • Redox signaling
  • Synaptic plasticity

ASJC Scopus subject areas

  • Sensory Systems
  • Neurology
  • Cognitive Neuroscience
  • Clinical Neurology
  • Behavioral Neuroscience


Dive into the research topics of 'Reactive Oxygen Species, Synaptic Plasticity, and Memory'. Together they form a unique fingerprint.

Cite this