Recent approaches targeting beta-amyloid for therapeutic intervention of Alzheimer's disease

Jung Eun Cho, Jin Ryoun Kim

Research output: Contribution to journalReview article

Abstract

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by neuropathological features comprising amyloid deposits and neuronal losses in brain. In AD, aggregation of a β-amyloid peptide (Aβ), produced from proteolytic cleavage of amyloid precursor protein, is believed to be implicated in the pathophysiological cascade leading to neuronal death. Most AD drugs currently available can only alleviate symptoms rather than modify the underlying molecular cause of AD. In this review, we describe and discuss the recent patents issued within the past two years focusing on therapeutic interventions targeting at various Aβ-associated pathological mechanisms of AD. The described therapeutic strategies include 1) reduction of synthesis of Aβ, 2) inhibition of Aβaggregation, 3) immunotherapeutic/enzymatic clearance of Aβ, 4) targeting other amyloidogenic proteins interacting with Aβand 5) amelioration of Aβdownstream toxic effects. Important issues to be considered for further improvement of therapeutic efficacy of these approaches are also discussed.

Original languageEnglish (US)
Pages (from-to)222-233
Number of pages12
JournalRecent Patents on CNS Drug Discovery
Volume6
Issue number3
DOIs
StatePublished - Sep 2011

Keywords

  • Aggregation
  • Alpha synuclein
  • Alzheimer's disease
  • Amyloid
  • Antibody
  • Beta amyloid
  • Tau

ASJC Scopus subject areas

  • Drug Discovery
  • Psychiatry and Mental health
  • Pharmacology (medical)

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