Recent developments in the identification of chemotherapeutics for Chagas Disease

Jeffrey W. Lockman, Andrew D. Hamilton

Research output: Contribution to journalReview article

Abstract

Chagas Disease, caused by the T. cruzi parasite, is one of the largest public health problems in the Western hemisphere. Although its spread has diminished due to vector eradication programs, effective chemotherapeutics for the disease itself remain elusive. Many efforts towards the development of antiparasitic agents active against a number of targets have been described recently in the literature. This review summarizes developments in trypanosidal agents from 2000 through 2003.

Original languageEnglish (US)
Pages (from-to)945-959
Number of pages15
JournalCurrent Medicinal Chemistry
Volume12
Issue number8
DOIs
StatePublished - Apr 14 2005

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

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