Recent trends in peptide and protein-based hydrogels

Priya Katyal, Farbod Mahmoudinobar, Jin Kim Montclare

Research output: Contribution to journalReview article

Abstract

Hydrogels are classic examples of biomaterials that have found its niche in biomedical and allied fields. Here, we describe examples of peptide-based and protein-based hydrogels with a focus on smart gels that respond to various stimuli including temperature, pH, light, and ionic strength. With the recent advancements in computational modeling, it has been possible to predict as well as design peptide and protein sequences that can assemble into hydrogels with unique and improved properties. We briefly discuss coarse grained and atomistic simulations in designing peptides that can form hydrogels. In addition, we highlight the trends that will influence the future design and applications of hydrogels, with emphasis on bioadhesion, exosomes delivery, tissue and organoids engineering, and even intracellular production of gels.

Original languageEnglish (US)
Pages (from-to)97-105
Number of pages9
JournalCurrent Opinion in Structural Biology
Volume63
DOIs
StatePublished - Aug 2020

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

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