Receptor-stimulated actin polymerization requires cytoplasmic acidification in human PMNs

Maurizio Tonetti, Michael Budnick, Richard Niederman

Research output: Contribution to journalArticle

Abstract

Cytoplasmic alkalinization has received considerable attention as a regulatory event In cell growth, transformation and signal transduction (Busa, W.B. (1986) Annu. Rev. Physiol. 48, 389-402 and Moolenar, W.H. (1986) Annu. Rev. Physiol. 48, 363-376). In contrast the current paper presents evidence for the role of an early cytoplasmic acidification, during signal transduction in the polymorphonuclear leukocyte (PMN). Following PMN stimulation with a chemotactic peptide, there is a significant decrease in cytoplasmic pH concomitant with a dramatic increase in cytoskeletal actin. The data indicate that this drop in pHi is necessary, but not sufficient, for signal transduction leading to cytoskeletal reorganization in these cells.

Original languageEnglish (US)
Pages (from-to)154-158
Number of pages5
JournalBBA - Molecular Cell Research
Volume1054
Issue number2
DOIs
StatePublished - Sep 1 1990

Keywords

  • Cell movement
  • Cytoskeleton
  • Granulocyte
  • Hydrogen-ion concentration

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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