Recognition of cytochrome C by tetraphenylporphyrin-based protein surface receptors

Rishi K. Jain, Lun K. Tsou, Andrew D. Hamilton

Research output: Chapter in Book/Report/Conference proceedingChapter


Cytochrome c (cyt. c) has become a major protein for testing new approaches and techniques in protein science.1 This is partly due to the venerable position that cytochrome c holds in the field of biochemistry since it was isolated and characterized more than 70 years ago. Cyt. c was one of the first proteins to be sequenced,2 and to have its X-ray structure determined in 1967.3 Cyt. c also has the advantage of stability and a spectroscopically distinct heme group. More than 23,000 articles mentioning cyt. c were published between 1945-2002 (ISI Web of Science). Here, we describe an approach to tetraphenylporphyrin-based protein surface receptors and the characterization of their interactions with the principal target cyt. c.

Original languageEnglish (US)
Title of host publicationMacrocyclic Chemistry
Subtitle of host publicationCurrent Trends and Future Perspectives
PublisherSpringer Netherlands
Number of pages9
ISBN (Print)1402033648, 9781402033643
StatePublished - 2005

ASJC Scopus subject areas

  • General Materials Science
  • General Chemistry


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