Recognition of EBV plasma membrane protein expressed on murine cells after gene transfer

C. S. Reiss, D. Wang, D. Ghosh, C. Gaposchkin, E. Kieff

Research output: Contribution to journalArticle

Abstract

The immune response to B lymphocytes infected with Epstein-Barr virus (EBV) prevents their over-growth in normal humans. A murine model is now described for analyzing the T cell immune response to Epstein-Barr virus genes expressed in murine lymphoblasts by gene transfer. In mice, a 60,000 dalton virus-encoded protein characteristically found in the plasma membrane of latently infected human lymphocytes readily induces both proliferative and cytolytic T lymphocytes specific for both the EBV protein and murine major histocompatibility proteins. Longterm cultures of L3T4+ cells, some of which were cytolytic, were found to be restricted by H-2I-E(d) and the latent membrane protein. Similarly, Lyt-2+ cells were cytolytic and were restricted by H-2L(d) and the lymphocyte membrane protein gene product. The similarity in murine and human effector cell responses suggests that this is a useful experimental model, and the EBV latent infection membrane protein may be an important antigen in the immune restriction of growth transformed latently infected lymphocytes.

Original languageEnglish (US)
Pages (from-to)711-714
Number of pages4
JournalJournal of Immunology
Volume139
Issue number3
StatePublished - 1987

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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