Recognition of neutral species with synthetic receptors

Heidi Chen, Warren S. Weiner, Andrew D. Hamilton

Research output: Contribution to journalArticlepeer-review


The design of synthetic receptors for neutral molecules is an area of intense current interest. The area has grown from early work on cyclodextrin or single crown ether complexation to encompass a wide array of receptor shapes and structures. Furthermore, the range of substrate selectivities has increased from simple aromatic or metal ion substrates to include key biological components such as peptides and carbohydrates. Recent advances have included the application of split bead combinatorial methods for the identification of receptors for oligopeptides, the design of self-assembling spherical receptors, the use of multiple hydrogen bonding groups for carboxylic acid and carbohydrate recognition and the achievement of impressive catalytic effects with synthetic receptors.

Original languageEnglish (US)
Pages (from-to)458-466
Number of pages9
JournalCurrent Opinion in Chemical Biology
Issue number4
StatePublished - Dec 1997

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry


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