Recognition of the α-1 and α-2 domains of H-2 molecules by allospecific cloned T cells

C. S. Reiss, J. L. Greenstein, M. A.V. Crimmins, L. L. Liu, A. Rao, R. T. Maziaraz, C. Murre, S. J. Burakoff

Research output: Contribution to journalArticle

Abstract

Previously we had shown that allospecific bulk cultures of cytolytic T lymphocytes lysed the products of cloned class I major histocompatibility genes expressed after DNA-mediated gene transfer. In these experiments, performed by using cloned allospecific T cell effectors, a T cell hybridoma, and recombinant DNA technology, we have been able to map determinants recognized by these T cell clones to the α-1 domain of H-2D(d) and the α-2 domain of H-2L(d) (four of eight clones). Target cells used were L cells (H-2(k)), expressing wild type or hybrid H-2 antigens of H-2(d) origin. Thus, for the first time determinants recognized by cloned T cells are found in the recombined α-1 and α-2 domains.

Original languageEnglish (US)
Pages (from-to)2191-2194
Number of pages4
JournalJournal of Immunology
Volume136
Issue number6
StatePublished - 1986

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Reiss, C. S., Greenstein, J. L., Crimmins, M. A. V., Liu, L. L., Rao, A., Maziaraz, R. T., Murre, C., & Burakoff, S. J. (1986). Recognition of the α-1 and α-2 domains of H-2 molecules by allospecific cloned T cells. Journal of Immunology, 136(6), 2191-2194.