@article{1ba772d319004a72ae9941f6ba8927bc,
title = "Reconfigurable Two-Dimensional DNA Lattices: Static and Dynamic Angle Control",
abstract = "Branched DNA motifs serve as the basic construction elements for all synthetic DNA nanostructures. However, precise control of branching orientation remains a key challenge to further heighten the overall structural order. In this study, we use two strategies to control the branching orientation. The first one is based on immobile Holliday junctions which employ specific nucleotide sequences at the branch points which dictate their orientation. The second strategy is to use angle-enforcing struts to fix the branching orientation with flexible spacers at the branch points. We have also demonstrated that the branching orientation control can be achieved dynamically, either by canonical Watson–Crick base pairing or non-canonical nucleobase interactions (e.g., i-motif and G-quadruplex). With precise angle control and feedback from the chemical environment, these results will enable novel DNA nanomechanical sensing devices, and precisely-ordered three-dimensional architectures.",
keywords = "DNA nanostructures, angle control, branching orientation, junction motif, self-assembly",
author = "Wen Wang and Chunyu Chen and Simon Vecchioni and Tianqing Zhang and Chengxian Wu and Ohayon, {Yoel P.} and Ruojie Sha and Seeman, {Nadrian C.} and Bryan Wei",
note = "Funding Information: We would like to thank David Millar for sharing his unpublished findings of the conformer ratios of the immobile Holliday junctions of different sequences, and Baoquan Ding for discussion. We acknowledge support of the following grants: Grant No. 31770926 from the National Natural Science Foundation of China, funds from Beijing Advanced Innovation Center for Structural Biology, and a startup fund from the Tsinghua University-Peking University Joint Center for Life Sciences (to B.W.); Grant No. GM-29554 from NIGMS, Grant Nos. CTS1120890, CCF-1117210, EFRI-1332411, and CHE-1708776 from the NSF, Grant No. W911NF-1110024 from ARO, Grant Nos. N000141110729 and N000140911118 from ONR, DESC0007991 from DOE for partial salary support and GBMF3849 from the Gordon and Betty Moore Foundation (to N.C.S.); Grant No. 2018M631448 from the China Postdoctoral Science Foundation and the Postdoctoral Fellowships from the Tsinghua University-Peking University Joint Center for Life Sciences (to W.W.). Funding Information: We would like to thank David Millar for sharing his unpublished findings of the conformer ratios of the immobile Holliday junctions of different sequences, and Baoquan Ding for discussion. We acknowledge support of the following grants: Grant No. 31770926 from the National Natural Science Foundation of China, funds from Beijing Advanced Innovation Center for Structural Biology, and a startup fund from the Tsinghua University‐Peking University Joint Center for Life Sciences (to B.W.); Grant No. GM‐29554 from NIGMS, Grant Nos. CTS1120890, CCF‐1117210, EFRI‐1332411, and CHE‐1708776 from the NSF, Grant No. W911NF‐1110024 from ARO, Grant Nos. N000141110729 and N000140911118 from ONR, DESC0007991 from DOE for partial salary support and GBMF3849 from the Gordon and Betty Moore Foundation (to N.C.S.); Grant No. 2018M631448 from the China Postdoctoral Science Foundation and the Postdoctoral Fellowships from the Tsinghua University‐Peking University Joint Center for Life Sciences (to W.W.). Publisher Copyright: {\textcopyright} 2021 Wiley-VCH GmbH.",
year = "2021",
month = dec,
day = "1",
doi = "10.1002/anie.202112487",
language = "English (US)",
volume = "60",
pages = "25781--25786",
journal = "Angewandte Chemie - International Edition",
issn = "1433-7851",
publisher = "John Wiley and Sons Ltd",
number = "49",
}