Reconfigurable Two-Dimensional DNA Lattices: Static and Dynamic Angle Control

Wen Wang, Chunyu Chen, Simon Vecchioni, Tianqing Zhang, Chengxian Wu, Yoel P. Ohayon, Ruojie Sha, Nadrian C. Seeman, Bryan Wei

Research output: Contribution to journalArticlepeer-review


Branched DNA motifs serve as the basic construction elements for all synthetic DNA nanostructures. However, precise control of branching orientation remains a key challenge to further heighten the overall structural order. In this study, we use two strategies to control the branching orientation. The first one is based on immobile Holliday junctions which employ specific nucleotide sequences at the branch points which dictate their orientation. The second strategy is to use angle-enforcing struts to fix the branching orientation with flexible spacers at the branch points. We have also demonstrated that the branching orientation control can be achieved dynamically, either by canonical Watson–Crick base pairing or non-canonical nucleobase interactions (e.g., i-motif and G-quadruplex). With precise angle control and feedback from the chemical environment, these results will enable novel DNA nanomechanical sensing devices, and precisely-ordered three-dimensional architectures.

Original languageEnglish (US)
Pages (from-to)25781-25786
Number of pages6
JournalAngewandte Chemie - International Edition
Issue number49
StatePublished - Dec 1 2021


  • DNA nanostructures
  • angle control
  • branching orientation
  • junction motif
  • self-assembly

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry


Dive into the research topics of 'Reconfigurable Two-Dimensional DNA Lattices: Static and Dynamic Angle Control'. Together they form a unique fingerprint.

Cite this