Recovery of memory following amnesia in the rat and mouse

David Quartermain, Bruce S. McEwen, Efrain C. Azmitia

Research output: Contribution to journalArticlepeer-review


Conducted 6 experiments with male Holtzman rats (n = 84) and male C57BL/6J strain mice (n = 278). Memory of 1-trial passive avoidance was disrupted by ECS or a protein synthesis inhibitor, cycloheximide. Results indicate that (a) reexposure of the amnesic S to the training apparatus was sufficient to initiate recovery, (b) a reminder shock catalyzed the rate of recovery of memory only when presented before or after reexposure to the training apparatus, (c) the recovered memory was as durable as the memory observed in Ss never treated with the amnesic agents, and (d) cycloheximide attenuated the recovery of memory in mice made amnesic by the same agent. This attenuation applied to memory recovered by reexposure to the apparatus alone or in combination with reminder shock given before or after the initial retention test. (15 ref.) (PsycINFO Database Record (c) 2006 APA, all rights reserved).

Original languageEnglish (US)
Pages (from-to)360-370
Number of pages11
JournalJournal of Comparative and Physiological Psychology
Issue number3
StatePublished - Jun 1972


  • ECS vs. cycloheximide, memory recovery of 1-trial passive avoidance after amnesia, rat &
  • mouse

ASJC Scopus subject areas

  • General Medicine


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