Reduced threshold for cortical spreading depression in female mice

Kevin C. Brennan, Marcela Romero Reyes, Héctor E.López Valdés, Arthur P. Arnold, Andrew C. Charles

Research output: Contribution to journalArticlepeer-review


The prevalence of migraine is much greater in female than male individuals. Cortical spreading depression (CSD) is thought to be a fundamental mechanism of migraine, and CSD in rodents is used as a model for migraine. We used optical intrinsic signal imaging and electrophysiological techniques to investigate CSD in C57Bl/6 mice. Using two different methods for induction of CSD, we found that female mice had a significantly reduced threshold for induction of CSD compared with male mice. These results suggest an increased cortical excitability in female mice that may be independent of the estrous cycle.

Original languageEnglish (US)
Pages (from-to)603-606
Number of pages4
JournalAnnals of Neurology
Issue number6
StatePublished - Jun 2007

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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