@article{8880c33df7b0416a9ba30eb5c999a21d,
title = "Reexpression of type IIA procollagen in adult osteoarthritic",
author = "Nah, {H. D.} and B. Swoboda and E. Koyama and Suh, {J. Y.} and W. Croll-Halpern and T. Kirsch",
note = "Funding Information: ent in marrows. Lymphatic organs were reduced to -80% that of controls, and displayed altered tissue architecture and lymphocyte content. In thymuses, a paucity of cortical CD3/CD4/CD8÷ lymphocytes was consistent with the marrow~'Es inability to replenish maturing T cells. Likewise, in spleens, an unaltered T cell distribution was coupled with diffuse staining for functional B cells; B cell reduction was prominent in the poorly organized lymphatic nodules, and underscored the effects of marrow aplasia. Disorderly arrays of splenic macrophages and a depletion of red pulp further complemented the data from Tg mutants. Moreover, subtle growth plate compressions and immune changes were seen in all null mice. Data from Tg and null mice implicate the disruption of collagen X function in the observed skeleto-hematopoietic defects and perinatal lethality. Furthermore, interbreeding of null and Tg mice is yielding insights into mechanisms of transgene action. (NIH AR43362, Arthritis Biomedical Grant, University of Pennsylvania Research Foundation to O J).",
year = "1998",
doi = "10.1016/s0945-053x(98)90043-9",
language = "English (US)",
volume = "17",
pages = "159",
journal = "Collagen and Related Research",
issn = "0945-053X",
publisher = "Elsevier",
number = "2",
}